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製品番号: HY-147771

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ZLWT-37

ZLWT-37 is a potent, orally active CDKs inhibitor with IC₅₀ values of 0.002 μM and 0.054 μM against CDK9 and CDK2, respectively. ZLWT-37 induces apoptosis and arrests the cell cycle in the G2/M phase in HCT116 cells.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2813347-44-1
分子式: C₂₆H₃₀ClN₅O
分子量:464.00

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ZLWT-37 構造式

CAS 番号: 2813347-44-1

容量

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

CDK9

0.002 μM (IC₅₀)

CDK2

0.054 μM (IC₅₀)

CDK アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	0.051 μM Compound: ZLWT-37	Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 36054949]
HCT-116	GI₅₀	0.029 μM Compound: ZLWT-37	Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 36054949]
MCF7	GI₅₀	0.109 μM Compound: ZLWT-37	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 36054949]
SW480	GI₅₀	0.328 μM Compound: ZLWT-37	Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay Antiproliferative activity against human SW480 cells assessed as cell growth inhibition after 72 hrs by MTT assay	[PMID: 36054949]

体外実験

ZLWT-37 shows antiproliferative activity with a GI₅₀ of 0.029 μM for HCT116^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

ZLWT-37 (0-20 mg/kg; p.o.; once daily for 14 consecutive days) shows potential efficacy against the growth of implanted HCT116 cells in mice without obvious toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2813347-44-1
分子量 464.00
分子式 C₂₆H₃₀ClN₅O
SMILES

N[C@H]1CCN(C1)C2=C3CCCCC3=NC4=C2C=C(C=C4)C5=CC=NC(NC(C6CC6)=O)=C5.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Liu W, et al. Discovery of novel tacrine derivatives as potent antiproliferative agents with CDKs inhibitory property. Bioorg Chem. 2022 Sep;126:105875. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献

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ZLWT-37

CDK アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

ZLWT-37 関連分類

HY-147771 関連分類