BMS-345541 hydrochloride
Based on 38 publication(s) in Google Scholar
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM, IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.94%
- CAS No.: 547757-23-3
- 화학식: C14H18ClN5
- 분자량:291.78
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
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Publications Citing Use of MedChemExpress (MCE) BMS-345541 hydrochloride
More- Cancer Cell. 2015 Mar 9;27(3):409-25. [Abstract]
- Cell Res. 2019 Mar;29(3):193-205. [Abstract]
- Nat Metab. 2023 Mar;5(3):481-494. [Abstract]
- Sci Transl Med. 2021 Jan 27;13(578):eaba7308. [Abstract]
- Interdiscip Med. 2026 May 18.
- Mol Biomed. 2026 Jun 23;7(1):94. [Abstract]
- J Immunother Cancer. 2026 Jun 3;14(6):e014253. [Abstract]
- Phytomedicine. 2026 Feb:151:157795. [Abstract]
- Am J Hematol. 2024 Jul;99(7):1326-1337. [Abstract]
- J Hazard Mater Adv. 2026 Mar 7.
- Int J Biol Macromol. 2025 Dec;334(Pt 1):149021. [Abstract]
- EMBO Mol Med. 2025 Nov 26. [Abstract]
- EMBO Mol Med. 2025 Apr;17(4):645-678. [Abstract]
- Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
- J Dent Res. 2019 Jul;98(8):896-903. [Abstract]
- Cancer Metab. 2024 Jul 8;12(1):20. [Abstract]
- Front Microbiol. 2021 Feb 2;12:607451. [Abstract]
- Int Immunopharmacol. 2021 Dec;101(Pt A):108264. [Abstract]
- Molecules. 2025 May 2;30(9):2025. [Abstract]
- J Mol Med. 2020 Oct;98(10):1479-1491. [Abstract]
- Cancer Sci. 2025 Nov 14. [Abstract]
- PLoS Pathog. 2025 Oct 24;21(10):e1013646. [Abstract]
- iScience. 2024 May 16;27(6):110011. [Abstract]
- Antiviral Res. 2026 May:249:106391. [Abstract]
- Am J Physiol Endocrinol Metab. 2021 Apr 1;320(4):E732-E746. [Abstract]
- J Virol. 2019 Nov 26;93(24):e01499-19. [Abstract]
- PLoS Comput Biol. 2020 Jun 26;16(6):e1007901. [Abstract]
- J Pharmacol Sci. 2023 Dec;153(4):188-196. [Abstract]
- Biochem Biophys Res Commun. 2023 Nov 5:680:127-134. [Abstract]
- J Vet Sci. 2023 Sep;24(5):e72. [Abstract]
- Photobiomodul Photomed Laser Surg. 2025 Jul 24. [Abstract]
- University of Pittsburgh. 2026.
- bioRxiv. 2026 Apr 22:2026.04.19.719504. [Abstract]
- bioRxiv. 2025 Oct 25.
- bioRxiv. 2025 Aug 13:2025.08.11.669793. [Abstract]
- Research Square Print. October 27th, 2022.
- Aging (Albany NY). 2021 Aug 10;13(15):19088-19107. [Abstract]
- Biomed Pharmacother. 2020 Jul;127:110116. [Abstract]
Customer Validation & Images
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WB
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Cell Migration/Invasion Assay
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RT-PCR
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Flow Cytometry
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IF
Biological Activity
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IKK-2 0.3 μM (IC50) |
IKK-1 4 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
9.3 μM
Compound: BMS-345541
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Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
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[PMID: 29351887] |
| HeLa 229 | IC50 |
9.4 μM
Compound: BMS-345541
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Antiproliferative activity against human HeLa 229 cells after 72 hrs by MTT assay
Antiproliferative activity against human HeLa 229 cells after 72 hrs by MTT assay
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[PMID: 29351887] |
| MGC-803 | IC50 |
14.2 μM
Compound: BMS-345541
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Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 72 hrs by MTT assay
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[PMID: 29351887] |
| SGC-7901 | IC50 |
8.3 μM
Compound: BMS-345541
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Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells after 72 hrs by MTT assay
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[PMID: 29351887] |
| THP-1 | IC50 |
4 μM
Compound: 1, BMS-345541
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Inhibition of LPS-induced TNFalpha secretion in THP1 cells
Inhibition of LPS-induced TNFalpha secretion in THP1 cells
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[PMID: 17197177] |
BMS-345541 inhibits IKK-2 and IKK-1 in dose-dependent manner. BMS-345541 fails to inhibit a panel of both serine/threonine and tyrosine kinases at concentrations as high as 100 μM. MS-345541 at concentrations as high as 100 μM fails to block both the anisomycin-stimulated phosphorylation of c-Jun and LPS-stimulated activation of MAPKAP K2 in THP-1 cells, as well as the EGF-stimulated phosphorylation of STAT3 in H292 cells[1].
BMS-345541 treatment results in a concentration-dependent inhibition of melanoma cell proliferation in SK-MEL-5, A375, and Hs 294T cells. BMS-345541 (0, 100 μM) shows apoptotic features as revealed by TUNEL staining and nuclear condensation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BMS-345541 (0, 10, 25, and 75 mg/kg, p.o.) effectively inhibits SK-MEL-5 tumor growth in a dose-dependent manner in the mice. Tumor-bearing mice treated with 75 mg/kg of BMS-345541 show effective inhibition of growth of SK-MEL-5, A375, and Hs 294T tumors by 86±2.8%, 69±11% and 67±3.4%, respectively[2].
BMS-345541 (30 and 100 mg/kg, p.o.) is effective in blocking both clinical and histological endpoints of inflammation and injury in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 547757-23-3
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Appearance Solid
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분자량 291.78
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화학식 C14H18ClN5
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Color White to off-white
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SMILES
CC1=CN=C2C(NCCN)=NC3=CC=C(C=C3N21)C.Cl
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (38)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia. [Abstract]2015 Mar 9;27(3):409-25. PMID: 25759025
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2015 Mar 9;27(3):409-25. [Abstract]
pre-BCR+ ALL cells, pre-BCR- ALL cells and mature B cell lymphoma cells were treated with BMS-345541 hydrochloride (1-64 μM) and cell viability was measured by CCK-8 at different dose levels.
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Cell Res
Virus-induced accumulation of intracellular bile acids activates the TGR5-β-arrestin-SRC axis to enable innate antiviral immunity. [Abstract]2019 Mar;29(3):193-205. PMID: 30651583 -
Nat Metab
2023 Mar;5(3):481-494. PMID: 36879120
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Metab. 2023 Mar;5(3):481-494. [Abstract]
Mt2gene expression in beige adipocytes treated with indicated compounds (50 ng/mL TNF, 2 μM BMS345541, 1 μM SCH772984, 5 μM SB202190 and 5 μM SP600125; n = 4 biological independent samples).
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Sci Transl Med
A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity. [Abstract]2021 Jan 27;13(578):eaba7308. PMID: 33504651 -
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Mol Biomed
Death-associated protein kinase 2 (DAPK2) propagates endoplasmic reticulum stress in macrophages to worsen sepsis through HSPA5-IRE1α axis. [Abstract]2026 Jun 23;7(1):94. PMID: 42334722 -
J Immunother Cancer
Chemotherapy induces an IL1β-dependent neutrophil recruitment and activation that promote chemoresistance in metastatic ovarian cancer. [Abstract]2026 Jun 3;14(6):e014253. PMID: 42236112 -
Phytomedicine
Complementary roles and synergy of the Ephedra-Glycyrrhiza herb pair across murine models of respiratory symptoms and poly(I:C)-induced pneumonia. [Abstract]2026 Feb:151:157795. PMID: 41539102 -
Am J Hematol
miR-146a-/- mice model reveals that NF-κB inhibition reverts inflammation-driven myelofibrosis-like phenotype. [Abstract]2024 Jul;99(7):1326-1337. PMID: 38646919 -
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Int J Biol Macromol
Lipocalin 2 deficiency attenuates NLRP3 inflammasome activation through glycolysis impairment and MGST1-mediated mitochondrial ROS reduction. [Abstract]2025 Dec;334(Pt 1):149021. PMID: 41260431 -
EMBO Mol Med
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice. [Abstract]2025 Nov 26. PMID: 41299101 -
EMBO Mol Med
Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy. [Abstract]2025 Apr;17(4):645-678. PMID: 39972068 -
Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
J Dent Res
2019 Jul;98(8):896-903. PMID: 31189369
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: J Dent Res. 2019 Jul;98(8):896-903. [Abstract]
A223 and FaDu cells were treated with 5 µM BMS345541 for 18 h, and wb was detected.
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Cancer Metab
Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species. [Abstract]2024 Jul 8;12(1):20. PMID: 38978126
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Metab. 2024 Jul 8;12(1):20. [Abstract]
The migratory activity of MCF7 or MDA-MB-231 cells was assessed 24 h after treatment ± NF-κB inhibitor BMS-345541 (10 µM).
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Front Microbiol
Cellular CARD11 Inhibits the Fusogenic Activity of Newcastle Disease Virus via CBM Signalosome-Mediated Furin Reduction in Chicken Fibroblasts. [Abstract]2021 Feb 2;12:607451. PMID: 33603723
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: Front Microbiol. 2021 Feb 2;12:607451. [Abstract]
BAY 11-7082, BMS-345541 (0.1-10 μM), and MI-2 at different concentrations for 24 h. These cells were observed and harvested to detect cell survival using flow cytometry. Scale bar = 50 μm.
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Int Immunopharmacol
Topoisomerase 2 inhibitor etoposide promotes interleukin-10 production in LPS-induced macrophages via upregulating transcription factor Maf and activating PI3K/Akt pathway. [Abstract]2021 Dec;101(Pt A):108264. PMID: 34715493 -
Molecules
Investigating Natural Product Inhibitors of IKKα: Insights from Integrative In Silico and Experimental Validation. [Abstract]2025 May 2;30(9):2025. PMID: 40363830 -
J Mol Med
Chemically modified curcumin (CMC2.24) alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis. [Abstract]2020 Oct;98(10):1479-1491. PMID: 32860098
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: J Mol Med. 2020 Oct;98(10):1479-1491. [Abstract]
BMS-345541 (5 μM; 2 h) greatly enhanced CMC2.24-mediated decrease in the translocation of p65 subunits to the nuclei of chondrocytes.
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: J Mol Med. 2020 Oct;98(10):1479-1491. [Abstract]
BMS-345541 (5 μM) remarkably enhanced CMC2.24-mediated decrease in MMP-3, cleaved caspase-3, VEGF, RUNX2, p-p65, p-IκB-α, and Hif-2α expression, and increase in Col2a1 and Bcl-2 expression in chondrocytes.
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Cancer Sci
NF-κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor-Resistant Cutaneous T-Cell Lymphoma. [Abstract]2025 Nov 14. PMID: 41236113 -
PLoS Pathog
Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis. [Abstract]2025 Oct 24;21(10):e1013646. PMID: 41134862
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2025 Oct 24;21(10):e1013646. [Abstract]
NL20 cells were infected with 0.1 MOI of H5N1 (SY) virus and then treated with the indicated concentrations of the JNK inhibitor (SP600125, SP), the IKK inhibitor (BMS345541, BMS, 0-10 μM) and the TAK1 inhibitor (5Z-oxzeneonal, 5Z) for 24 h. Cell lysates were prepared and analyzed for the levels of the PB2 and NP proteins by Western blots. GAPDH was detected as a loading control.
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iScience
Transcriptional synergy in human aortic endothelial cells is vulnerable to combination p300/CBP and BET bromodomain inhibition. [Abstract]2024 May 16;27(6):110011. PMID: 38868181 -
Antiviral Res
Porcine epidemic diarrhea virus infection activates SREBP2 and induces RORγ expression to enhance cholesterol biosynthesis and virus replication. [Abstract]2026 May:249:106391. PMID: 41796918 -
Am J Physiol Endocrinol Metab
1,25-Dihydroxyvitamin D deficiency accelerates male reproductive senescence in aging mice and 1,25(OH)2D3 alleviates oxidative stress via NF-κB/SOD. [Abstract]2021 Apr 1;320(4):E732-E746. PMID: 33586492 -
J Virol
Host CARD11 Inhibits Newcastle Disease Virus Replication by Suppressing Viral Polymerase Activity in Neurons. [Abstract]2019 Nov 26;93(24):e01499-19. PMID: 31554683 -
PLoS Comput Biol
A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics. [Abstract]2020 Jun 26;16(6):e1007901. PMID: 32589666 -
J Pharmacol Sci
Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells. [Abstract]2023 Dec;153(4):188-196. PMID: 37973216 -
Biochem Biophys Res Commun
Engrailed 2 triggers the activation of multiple phosphorylation-induced signaling pathways in both transcription-dependent and -independent manners. [Abstract]2023 Nov 5:680:127-134. PMID: 37738902 -
J Vet Sci
Subcutaneous Streptococcus dysgalactiae GAPDH vaccine in mice induces a proficient innate immune response. [Abstract]2023 Sep;24(5):e72. PMID: 38031651 -
Photobiomodul Photomed Laser Surg
Photobiomodulation Promotes Odontoblast-Like Cell Activity via Reactive Oxygen Species and NF-κB: Implications for Dentin Regeneration. [Abstract]2025 Jul 24. PMID: 40711932 -
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bioRxiv
CDK4/6 inhibition sensitizes breast cancer to NK cell therapy by inducing immune-interactive surface proteins. [Abstract]2026 Apr 22:2026.04.19.719504. PMID: 42079201 -
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bioRxiv
2025 Aug 13:2025.08.11.669793. PMID: 40832193 -
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Aging (Albany NY)
2021 Aug 10;13(15):19088-19107. PMID: 34375950 -
Biomed Pharmacother
2020 Jul;127:110116. PMID: 32428833
BMS-345541 hydrochloride purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2020 Jul;127:110116. [Abstract]
Relative NFκB, p-NFκB, p-IKBα and t-IKBα protein levels in spheres in the control, TNFα, TNFα + BMS-345541 and TNFα + resveratrol groups.
용액&용해도
H2O : 50 mg/mL (171.36 mM; Need ultrasonic)
DMSO : 20 mg/mL (68.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (6.85 mM); Clear solution
This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Assays measuring the enzyme-catalyzed phosphorylation of GST-IκBα are performed by adding enzyme (IKK-2, IKK-1, or IKK-ε, typically to a final concentration of 0.5 μg/mL) at 30°C to solutions of 100 μg/mL GST-IκBα and 5 μM [33P]ATP in 40 mMTris·HCl, pH 7.5, containing 4 mM MgCl2, 34 mM sodium phosphate, 3 mM NaCl, 0.6 mM potassium phosphate, 1 mM KCl, 1 mM dithiothreitol, 3% (w/v) glycerol, and 250 μg/mL bovine serum albumin. The specific activity of [33P]ATP used in the assay is 100 Ci/mmol. After 5 min, the kinase reactions are stopped by the addition of 2× LaemmLi sample buffer and heat-treated at 90°C for 1 min. The samples are then loaded on to NuPAGE 10% BisTris gels. After completion of SDS-PAGE, gels are dried on a slab gel dryer. The bands are then detected using a 445Si PhosphorImager, and the radioactivity is quantified using ImageQuant software. Under these conditions, the degree of phosphorylation of GST-IκBα is linear with time and concentration of enzyme.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Briefly, SK-MEL-5 cells are treated with BMS-345541 at different concentrations or for different time periods. The cells are collected by trypsinization, fixed in 70% ethanol for 2 hours on ice and stained with PI solution (PBS containing 2 μg/mL PI, 0.1% Triton X-100, and 125 units/mL RNase A) at 37°C for 30 minutes. Cell fluorescence is measured by flow cytometry with 488 nm excitation and 620 nm emission filters and resulting data are analyzed using the software program MultiCycle.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
BMS-345541 is administered either by intravenous tail vein injection or by peroral gavage to groups of three 18-22-g female BALB/c mice. BMS-345541 is formulated as a 2 mg/mL solution in 3% Tween 80, water. Mice receive either a 2 mg/kg (1 mL/kg) intravenous bolus or a 10 mg/kg (5 mL/kg) peroral gavage. Whole blood samples are taken from individual mice by orbital bleed and cardiac puncture at 0, 0.05, 0.25, 0.5, 1.0, 3.0, 6.0, and 8.0 h after dosing. Whole blood is centrifuged at 20×103×g for 5 min. Serum is stored at −20°C until analysis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
순도&문서
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Data Sheet (281 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456. [Content Brief]
[2]. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960. [Content Brief]
[3]. MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.4272 mL | 17.1362 mL | 34.2724 mL | 85.6810 mL |
| 5 mM | 0.6854 mL | 3.4272 mL | 6.8545 mL | 17.1362 mL | |
| 10 mM | 0.3427 mL | 1.7136 mL | 3.4272 mL | 8.5681 mL | |
| 15 mM | 0.2285 mL | 1.1424 mL | 2.2848 mL | 5.7121 mL | |
| 20 mM | 0.1714 mL | 0.8568 mL | 1.7136 mL | 4.2840 mL | |
| 25 mM | 0.1371 mL | 0.6854 mL | 1.3709 mL | 3.4272 mL | |
| 30 mM | 0.1142 mL | 0.5712 mL | 1.1424 mL | 2.8560 mL | |
| 40 mM | 0.0857 mL | 0.4284 mL | 0.8568 mL | 2.1420 mL | |
| 50 mM | 0.0685 mL | 0.3427 mL | 0.6854 mL | 1.7136 mL | |
| 60 mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.4280 mL | |
| H2O | 80 mM | 0.0428 mL | 0.2142 mL | 0.4284 mL | 1.0710 mL |
| 100 mM | 0.0343 mL | 0.1714 mL | 0.3427 mL | 0.8568 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BMS-345541 hydrochloride Related Classifications
HY-10518 Related Classifications
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