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Cat. No.: HY-16261A

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MC-DOXHZN

(Synonyms: (E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone)

5 Cited Publications

고객리뷰

Based on 5 publication(s) in Google Scholar

MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 151038-96-9
화학식: C₃₇H₄₂N₄O₁₃
분자량:750.75

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

MC-DOXHZN Chemical Structure

CAS No.: 151038-96-9

사이즈

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Top Publications Citing

Use of MCE Products

One-stop CDMO Service

One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

Daunorubicins/Doxorubicins

All ADC Payloads Isoforms :

All Topoisomerase Isoforms :

In Vitro

MC-DOXHZN conjugates to DTT-thiolated monoclonal antibodies (chimeric BR96, BR64, L6, human IgG) to form stable thioether-linked immunoconjugates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 151038-96-9
분자량 750.75
화학식 C₃₇H₄₂N₄O₁₃
SMILES

[H][C@@]1(O[C@H]2C[C@@](/C(CO)=N\NC(CCCCCN3C(C=CC3=O)=O)=O)(O)CC(C2=C4O)=C(O)C5=C4C(C6=C(OC)C=CC=C6C5=O)=O)O[C@@H](C)[C@@H](O)[C@@H](N)C1
Synonyms

(E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (5)

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Journal Impact Factor

Int J Pharm

Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. [Abstract]

2016 Oct 15;512(1):1-13. PMID: 27521706
Mol Pharm

Albumin Binding Domain Fusing R/K-X-X-R/K Sequence for Enhancing Tumor Delivery of Doxorubicin. [Abstract]

2017 Nov 6;14(11):3739-3749. PMID: 28950700
Mol Pharm

Acid-Sensitive Peptide-Conjugated Doxorubicin Mediates the Lysosomal Pathway of Apoptosis and Reverses Drug Resistance in Breast Cancer. [Abstract]

2015 Jul 6;12(7):2217-28. PMID: 26035464
Bioconjug Chem

Microenvironmental Control of MUC1 Aptamer-Guided Acid-Labile Nanoconjugate within Injectable Microporous Hydrogels. [Abstract]

2017 Oct 18;28(10):2530-2537. PMID: 28949511
China Biotechnology

2017, 37(4): 68-75.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Willner D, et al. (6-Maleimidocaproyl)hydrazone of doxorubicin--a new derivative for the preparation of immunoconjugates of doxorubicin. Bioconjug Chem. 1993;4(6):521-527. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MC-DOXHZN

5 Cited Publications

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (5)
순도&문서
References

상품명:
Cat. No.:
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MC-DOXHZN

Publications Citing Use of MedChemExpress (MCE) MC-DOXHZN

All ADC Payloads Isoforms

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Publications (5)

순도&문서

References

Calculators

Help & FAQs

MC-DOXHZN Related Classifications

HY-16261A Related Classifications