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Diclofenac

24 Cited Publications
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Based on 24 publication(s) in Google Scholar

Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade.

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  • Purity: 99.92%
  • CAS No.: 15307-86-5
  • 화학식: C14H11Cl2NO2
  • 분자량:296.15
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Diclofenac Chemical Structure
    Diclofenac Chemical Structure
  • Experimental Validation Results for Diclofenac
  • Experimental Validation Results for Diclofenac
  • Experimental Validation Results for Diclofenac
  • Experimental Validation Results for Diclofenac
CAS No.: 15307-86-5
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  • Diclofenac Chemical Structure
    Diclofenac Chemical Structure
    1/16
  • 1/16

    Diclofenac purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     KATOIII and KATO/DDP were treated with different concentration of Diclofenac (DCF) (0–1000 µM) for 48 h, and cell viability was assessed.

  • 1/16

    Diclofenac purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The KATO/DDP cells were treated with Cisplatin alone or cisplatin in combination with Diclofenac (DCF) at 10 or 20 µM for 24 h, at 37 °C. The apoptosis cells were detected by using annexin V and PI staining and analyzed by flow cytometer.

  • 1/16

    Diclofenac purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The combination effect of Diclofenac (DCF) (0, 5, 10, 20 μM) and Cisplatin on the expression of cleaved PARP in KATO/DDP cells was examined by Western blot analysis.

  • 1/16

    Diclofenac purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2022 Oct 11;23(20):12066. [Abstract]

    Customer Validation
     The formation of autophagic vacuoles in KATO/DDP cells increased from 27% to 39% and 45% in cotreatments involving cisplatin and Diclofenac (DCF) at 10 and 20 μM, respectively, when compared with treatment of cisplatin alone.

  • Diclofenac