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Cat. No.: HY-182766

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AMX-883

AMX-883 a selective and orally active BRD9 molecular glue degrader that drives differentiation in acute myeloid leukaemia. AMX-883 shows selectivity over all other bromodomain containing proteins and proteome wide. AMX-883 does not employ the commonly used E3 ligases (cereblon, VHL) but instead drives degradation via DCAF16 as a targeted glue. AMX-883 can be used for the study of acute myeloid leukaemia (AML).

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CAS No.: 3102636-19-8
화학식: C₄₅H₅₈FN₅O₅
분자량:767.97

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

AMX-883 Chemical Structure

CAS No.: 3102636-19-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
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Biological Activity

제품 설명

IC₅₀ & Target^[1]

BRD9

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In Vitro

Combination of AMX-883 with Venetoclax (HY-15531) resulted in synergistic efficacy in MV4-11 and MOLM-13 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AMX-883 (14 days) induced dose-dependent degradation of BRD9 in a luciferase-labeled MV4-11 dissemination model, accompanied by time-dependent induction of CD11b and CD86. Measurements of total disease burden in animals showed a significant reduction in tumor burden in the AMX-883-treated groups compared to the vector control group^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3102636-19-8
분자량 767.97
화학식 C₄₅H₅₈FN₅O₅
SMILES

COC(C=C(C(C(C)=C1C)=CN(C)C1=O)C=C2OC)=C2CN(CC3)CC4(CC4)N3CC5=C6C([C@H](N(CC6)C(/C(C#N)=C/C(C)(C)CF)=O)C(C)C)=CC(OC)=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Martin O'Rourke, et al. Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro. Blood (2025) 146 (Supplement 1): 1489.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

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AMX-883

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

AMX-883 Related Classifications

HY-182766 Related Classifications