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Cat. No.: HY-121081

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BAY-958

BAY-958 is a potent PTEFb/CDK9 inhibitor with high selectivity demonstrated, particularly within the CDK family. BAY-958 shows strong antiproliferative activity against cancer cell lines such as HeLa and MOLM-13. BAY-958 exhibits good metabolic stability. BAY-958 effectively inhibits tumor growth in mouse xenograft models without significant toxicity.

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CAS No.: 1335490-39-5
화학식: C₁₇H₁₆FN₅O₃S
분자량:389.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BAY-958 Chemical Structure

CAS No.: 1335490-39-5

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All CDK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	1 μM Compound: 40	Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining method	[PMID: 32866383]
HeLa	IC₅₀	1 μM Compound: 49; BAY-958	Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay Antiproliferative activity against human HeLa cells incubated for 96 hrs by crystal violet staining assay	[PMID: 32870008]
MOLM-13	IC₅₀	280 nM Compound: 40	Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining method	[PMID: 32866383]
MOLM-13	IC₅₀	280 nM Compound: 49; BAY-958	Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay Antiproliferative activity against human MOLM-13 cells incubated for 96 hrs by crystal violet staining assay	[PMID: 32870008]

Chemical Information

CAS No. 1335490-39-5
분자량 389.40
화학식 C₁₇H₁₆FN₅O₃S
SMILES

O=S(CC1=CC=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=C1)(N)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Identification of atuveciclib (BAY 1143572), the first highly selective, clinical PTEFb/CDK9 inhibitor for the treatment of cancer

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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