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Cat. No.: HY-111164

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CBS-3595

CBS-3595 is a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 with anti-inflammatory and anti-allodynic activities. CBS-3595 reduces the production of the proinflammatory cytokine IL-6 and increases the levels of the anti-inflammatory cytokine IL-10 in rats. CBS-3595 reduces paw oedema formation in the Complete Freund’s adjuvant (CFA) (HY-153808)-induced arthritis rat model. CBS-3595 is promising for research of autoimmune diseases.

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CAS No.: 908380-97-2
화학식: C₁₈H₁₇FN₄O₂S
분자량:372.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CBS-3595 Chemical Structure

CAS No.: 908380-97-2

사이즈

가격

재고

수량

Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All p38 MAPK Isoforms :

All Phosphodiesterase (PDE) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	213 μM Compound: 1; CBS-3595	Inhibition of human ERG expressed in HEK293 cells by patch clamp method Inhibition of human ERG expressed in HEK293 cells by patch clamp method	[PMID: 28613871]

Chemical Information

CAS No. 908380-97-2
분자량 372.42
화학식 C₁₈H₁₇FN₄O₂S
SMILES

CC(NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=C(S(C)=O)N2C)=C1)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Koch DA, et al. Efficacy and gastrointestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats. Rheumatology (Oxford). 2014 Mar;53(3):425-32. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

상품명:
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수량:
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상품명:
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CBS-3595

All p38 MAPK Isoforms

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

CBS-3595 Related Classifications

HY-111164 Related Classifications