DN401
Based on 1 publication(s) in Google Scholar
DN401 is a potent TRAP1 inhibitor with an IC50 of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC50 of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities.
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- Purity: 98.64%
- CAS No.: 2135749-60-7
- 화학식: C13H9BrClN5O2
- 분자량:382.60
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) DN401
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Biological Activity
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TRAP1 79 nM (IC50) |
HSP90 698 nM (IC50) |
DN401 (5-20 µM; 24 hours) has superior cancer-specific cytotoxicity but reduced cytotoxic effects in normal cells[1].
DN401 (20 µM; 6 hours) inhibits the expression of Chk1 and Akt in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, SK-HEP-1, T98G, H460, and PC3 cells
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Concentration:5 µM, 10 µM, 15 µM, 20 µM
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Incubation Time:24 hours
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Result:Exhibited cytotoxic activity.
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Cell Line:HeLa cells
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Concentration:20 µM
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Incubation Time:6 hours
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Result:Inhibited the expression of Chk1 and Akt.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:6-week-old BALB/c nu/nu male mice injected with PC3 cells[1]
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Dosage:30 mg/kg
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Administration:ip; once daily; for 14 days
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Result:Reduced tumor growth.
Chemical Information
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CAS No. 2135749-60-7
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Appearance Solid
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분자량 382.60
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화학식 C13H9BrClN5O2
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Color Off-white to light yellow
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SMILES
NC1=NC(Cl)=C2C(N(N=C2)CC3=C(C=C4OCOC4=C3)Br)=N1
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Synonyms
Panvotinib-401; Pan-401
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Photochem Photobiol B
Targeting TNF-SDH axis in macrophages reverses abnormal succinate metabolism and M1 polarization to alleviate UVB-induced skin damage. [Abstract]2026 May:278:113433. PMID: 41921367
용액&용해도
DMSO : 17.5 mg/mL (45.74 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6137 mL | 13.0685 mL | 26.1370 mL | 65.3424 mL |
| 5 mM | 0.5227 mL | 2.6137 mL | 5.2274 mL | 13.0685 mL | |
| 10 mM | 0.2614 mL | 1.3068 mL | 2.6137 mL | 6.5342 mL | |
| 15 mM | 0.1742 mL | 0.8712 mL | 1.7425 mL | 4.3562 mL | |
| 20 mM | 0.1307 mL | 0.6534 mL | 1.3068 mL | 3.2671 mL | |
| 25 mM | 0.1045 mL | 0.5227 mL | 1.0455 mL | 2.6137 mL | |
| 30 mM | 0.0871 mL | 0.4356 mL | 0.8712 mL | 2.1781 mL | |
| 40 mM | 0.0653 mL | 0.3267 mL | 0.6534 mL | 1.6336 mL |
DN401 Related Classifications
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