DSPE-PEG2000-cRGD
Based on 1 Customer Validation
DSPE-PEG2000-cRGD is a PEG compound which composed of DSPE and an αvβ3 targeting peptide (cRGD). cRGD peptide can specifically bind to αvβ3 on the surface of many cancer cells and neovascular cells. DSPE-PEG2000-cRGD can be used for drug delivery.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity : 95.0%
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
αvβ3 |
In Vitro
DSPE-PEG2000-cRGD can be used to construct pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD (PCNR). pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD nanoparticles can specifically target tumor cells that highly express integrin αvβ3[2].
Incorporating DSPE-PEG2000-cRGD into liposomes can form spatially stable and integrin-targeting liposomes[3].
DSPE-PEG2000-cRGD can be used to construct C-siRNA/MTSLR-U and C-siRNA/MTSLR, which have anti-hepatocellular carcinoma activity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
-
Appearance Solid
-
Color White to off-white
-
SMILES
[Cyclo(RGD-{d-Phe}-K)]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
순도&문서
-
Data Sheet (278 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Gajbhiye KR, et al. cRGD functionalised nanocarriers for targeted delivery of bioactives. J Drug Target. 2019 Feb;27(2):111-124. [Content Brief]
[2]. Zhang Y, et al. Construction of a Targeting Nanoparticle of 3',3″-Bis-Peptide-siRNA Conjugate/Mixed Lipid with Postinserted DSPE-PEG2000-cRGD. Mol Pharm. 2019 Dec 2;16(12):4920-4928. [Content Brief]
[3]. Khabazian E, et al. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. J Drug Target. 2022 Jun;30(5):522-533. [Content Brief]
[4]. Nai J, et al. Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells. Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG2000-cRGD Related Classifications
HY-172464 Related Classifications
Powered by Bioz