EN171
Based on 1 Customer Validation
EN171 is a covalent ligand that covalently targets both C38 and C96 on 14-3-3 to enhance 14-3-3 interactions with ERα, YAP and TAZ, leading to impaired estrogen receptor and Hippo pathway transcriptional activity. EN171 can not only be used as a molecular glue to enhance native protein interactions but can also be used as a covalent 14-3-3 recruiter in heterobifunctional molecules to sequester nuclear neo-substrates such as BRD4 and BLC6 into the cytosol.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.14%
- CAS No.: 2191110-79-7
- 화학식: C17H22N2O
- 분자량:270.37
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보관:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Chemical Information
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CAS No. 2191110-79-7
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Appearance Oil
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분자량 270.37
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화학식 C17H22N2O
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Color Colorless to off-white
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SMILES
O=C(N1CCC2(CN(CC2)CC3=CC=CC=C3)C1)C=C
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 25 mg/mL (92.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6986 mL | 18.4932 mL | 36.9864 mL | 92.4659 mL |
| 5 mM | 0.7397 mL | 3.6986 mL | 7.3973 mL | 18.4932 mL | |
| 10 mM | 0.3699 mL | 1.8493 mL | 3.6986 mL | 9.2466 mL | |
| 15 mM | 0.2466 mL | 1.2329 mL | 2.4658 mL | 6.1644 mL | |
| 20 mM | 0.1849 mL | 0.9247 mL | 1.8493 mL | 4.6233 mL | |
| 25 mM | 0.1479 mL | 0.7397 mL | 1.4795 mL | 3.6986 mL | |
| 30 mM | 0.1233 mL | 0.6164 mL | 1.2329 mL | 3.0822 mL | |
| 40 mM | 0.0925 mL | 0.4623 mL | 0.9247 mL | 2.3116 mL | |
| 50 mM | 0.0740 mL | 0.3699 mL | 0.7397 mL | 1.8493 mL | |
| 60 mM | 0.0616 mL | 0.3082 mL | 0.6164 mL | 1.5411 mL | |
| 80 mM | 0.0462 mL | 0.2312 mL | 0.4623 mL | 1.1558 mL |
EN171 Related Classifications
HY-W1005067 Related Classifications
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