FPT
Based on 1 Customer Validation
FPT, a 2-Aminotetralin, is an efficacious partial agonist at 5-HT1AR, a full agonist at 5-HT1BR and 5-HT1DR with EC50s of 39.3 nM, 1.2 nM, 0.5 nM, respectively. FPT is a weak agonist at 5-HT7R. FPT shows in vivo efficacy as an antiepileptic in Fmr1 knockout mice and has anxiolytic-like and prosocial effects in Fmr1 knockout mice and other mouse models.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.06%
- CAS No.: 2048491-06-9
- 화학식: C18H20FN
- 분자량:269.36
-
보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
|
5-HT1A Receptor 39.3 nM (IC50) |
5-HT1A Receptor |
5-HT1B Receptor |
5-HT1D Receptor |
5-HT1B Receptor 1.2 nM (IC50) |
5-HT1D Receptor 0.5 nM (IC50) |
5-HT1A Receptor 4.3 nM (Ki) |
5-HT1B Receptor 2.3 nM (Ki) |
5-HT1D Receptor 1.2 nM (Ki) |
5-HT1F Receptor >10,000 nM (Ki) |
5-HT7 Receptor |
Chemical Information
-
CAS No. 2048491-06-9
-
Appearance Liquid (Density: 1.119±0.10 g/cm3)
-
분자량 269.36
-
화학식 C18H20FN
-
Color Colorless to light yellow
-
SMILES
FC1=C(C=CC=C1)C2=C3C(C[C@H](CC3)N(C)C)=CC=C2
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 66.67 mg/mL (247.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
-
Data Sheet (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7125 mL | 18.5625 mL | 37.1250 mL | 92.8126 mL |
| 5 mM | 0.7425 mL | 3.7125 mL | 7.4250 mL | 18.5625 mL | |
| 10 mM | 0.3713 mL | 1.8563 mL | 3.7125 mL | 9.2813 mL | |
| 15 mM | 0.2475 mL | 1.2375 mL | 2.4750 mL | 6.1875 mL | |
| 20 mM | 0.1856 mL | 0.9281 mL | 1.8563 mL | 4.6406 mL | |
| 25 mM | 0.1485 mL | 0.7425 mL | 1.4850 mL | 3.7125 mL | |
| 30 mM | 0.1238 mL | 0.6188 mL | 1.2375 mL | 3.0938 mL | |
| 40 mM | 0.0928 mL | 0.4641 mL | 0.9281 mL | 2.3203 mL | |
| 50 mM | 0.0743 mL | 0.3713 mL | 0.7425 mL | 1.8563 mL | |
| 60 mM | 0.0619 mL | 0.3094 mL | 0.6188 mL | 1.5469 mL | |
| 80 mM | 0.0464 mL | 0.2320 mL | 0.4641 mL | 1.1602 mL | |
| 100 mM | 0.0371 mL | 0.1856 mL | 0.3713 mL | 0.9281 mL |
FPT Related Classifications
HY-160887 Related Classifications
Powered by Bioz