Garcinol
Based on 5 publication(s) in Google Scholar
Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.
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- Purity: 98.85%
- CAS No.: 78824-30-3
- 화학식: C38H50O6
- 분자량:602.80
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Publications Citing Use of MedChemExpress (MCE) Garcinol
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Biological Activity
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AChE |
BChE |
GCN5/PCAF |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf21 | IC50 |
5 μM
Compound: 92
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Inhibition of FLAG epitope-tagged recombinant human PCAF expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting
Inhibition of FLAG epitope-tagged recombinant human PCAF expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintillation counting
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10.1039/C1MD00199J |
| Sf21 | IC50 |
7 μM
Compound: 92
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Inhibition of His6-tagged recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintill
Inhibition of His6-tagged recombinant full length p300 (unknown origin) expressed in baculovirus infected insect Sf21 cells using [3H]acetyl-CoA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by liquid scintill
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10.1039/C1MD00199J |
Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner[3].
Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells[3].
Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CAL27 and UMSCC1 cells
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Concentration:10, 25, 50 µM
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Incubation Time:24, 48, and 72 hours
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Result:Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.
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Cell Line:CAL27 and UMSCC1 cells
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Concentration:10, 25, 50 µM
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Incubation Time:24, 48, and 72 hours
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Result:Induced apoptosis in HNSCC cells.
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Cell Line:CAL27 cells
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Concentration:50 µM
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Incubation Time:1, 2, 4, 6 hours
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Result:Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors[3]
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Dosage:1 and 2 mg/kg
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Administration:I.p.; five times/week for 4 consecutive weeks
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Result:Induced significant inhibition of tumor growth.
Chemical Information
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CAS No. 78824-30-3
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Appearance Solid
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분자량 602.80
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화학식 C38H50O6
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Color Light yellow to yellow
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SMILES
C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Sci Adv
A genetic screen for modifiers of cohesin clustering identifies regulators of genome folding. [Abstract]2026 Jan 30;12(5):eadx5130. PMID: 41616049 -
Int J Biol Macromol
Nucleocytoplasmic shuttling of sirtuin 1 regulates histone modifications and transcriptional events during early porcine embryonic development. [Abstract]2025 Dec;334(Pt 2):149016. PMID: 41265588
Garcinol purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Dec;334(Pt 2):149016. [Abstract]
Rate of blastocyst formation following Garcinol treatment at different concentrations (1, 5, and 10 μM).
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Liver Int
Inhibition of ACSS2 attenuates alcoholic liver steatosis via epigenetically regulating de novo lipogenesis. [Abstract]2023 Aug;43(8):1729-1740. PMID: 37183518 -
Int Immunopharmacol
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway. [Abstract]2025 Apr 4:151:114352. PMID: 40022821
Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352. [Abstract]
CCK8 assay results of HUVECs in the Garcinol-treated group.
Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352. [Abstract]
Garcinol (4 μM). Banding and quantitative analysis of VEGFA, VEGFR1 and FGF21 protein expression in different groups.
Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352. [Abstract]
Garcinol (4 μM) reduced the inflammatory response of macrophages to hyperglycemic stimulation. Representative images of iNOS staining and quantitative analysis.
Garcinol purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Apr 4:151:114352. [Abstract]
Garcinol promotes wound healing in diabetic mice. Representative H&E stained sections of wound samples from the backs of mice in each group on days 7 and 21.
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용액&용해도
DMSO : 50 mg/mL (82.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (284 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
References
[1]. Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12(8):1548-57. [Content Brief]
[2]. Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106(9):3963-86. [Content Brief]
[3]. Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila). 2013 Aug;6(8):843-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 1.6589 mL | 8.2946 mL | 16.5893 mL | 41.4731 mL |
| 5 mM | 0.3318 mL | 1.6589 mL | 3.3179 mL | 8.2946 mL | |
| 10 mM | 0.1659 mL | 0.8295 mL | 1.6589 mL | 4.1473 mL | |
| 15 mM | 0.1106 mL | 0.5530 mL | 1.1060 mL | 2.7649 mL | |
| 20 mM | 0.0829 mL | 0.4147 mL | 0.8295 mL | 2.0737 mL | |
| 25 mM | 0.0664 mL | 0.3318 mL | 0.6636 mL | 1.6589 mL | |
| 30 mM | 0.0553 mL | 0.2765 mL | 0.5530 mL | 1.3824 mL | |
| DMSO | 40 mM | 0.0415 mL | 0.2074 mL | 0.4147 mL | 1.0368 mL |
| 50 mM | 0.0332 mL | 0.1659 mL | 0.3318 mL | 0.8295 mL | |
| 60 mM | 0.0276 mL | 0.1382 mL | 0.2765 mL | 0.6912 mL | |
| 80 mM | 0.0207 mL | 0.1037 mL | 0.2074 mL | 0.5184 mL |
Garcinol Related Classifications
HY-107569 Related Classifications
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