Mertk - MER proto-oncogene tyrosine kinase Gene

Also Known as Eyk; Mer; Nyk; nmf12

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17289

Summary

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including animal organ development; neutrophil clearance; and protein kinase B signaling. Predicted to be located in several cellular components, including extracellular space; photoreceptor outer segment; and rhabdomere. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (Mer proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Mertk Products (1)

mRNA Protein Name
NM_008587.2 NP_032613.1 tyrosine-protein kinase Mer precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic cell clearance IDA
IDA: Inferred from direct assay
29440417 MGI
acts upstream of or within apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
18159085 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
17442946 MGI
involved in apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
18159085 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
16751775 MGI
acts upstream of or within negative regulation of cytokine production IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within neutrophil clearance IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15650770 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
18393392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Mer

  • Tyro 12

  • c-mer proto-oncogene tyrosine kinase

  • proto-oncogene c-Mer

  • proto-oncogene tyrosine-protein kinase Mer

  • receptor tyrosine kinase MerTK

Recombinant Mertk Proteins

Cat. No. 상품명 Accession Purity
HY-P73289 Mer Protein, Mouse (Active, sf9, His-GST) Q60805 (E573-Y867) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73820 Mer Protein, Mouse (HEK293, Fc) Q60805 (M1-F498) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700446 MERTK Protein, Mouse (HEK293, His) Q60805 (G19-M497) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명 효과
Purity Phase
HY-101549 MRX-2843 Inhibitor 99.92% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-147218 PF-07265807 Inhibitor 95.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-12344 UNC2025 Inhibitor 99.92% Unkown
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-125510 UNC2541 Inhibitor 99.71% Unkown
HY-12344A UNC2025 hydrochloride Inhibitor 99.96% Unkown
HY-117548 UNC1062 98.92% Unkown
HY-173268 UNC9426 Inhibitor 99.51% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-162940 MerTK/Axl-IN-1 Inhibitor / Unkown
HY-172796 UNC9435 Inhibitor 98.08% Unkown
HY-RS08340 MERTK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N9454 Garcinoic acid / Unkown
HY-RS16678 Mertk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131909 CJ-2360 Inhibitor / Unkown
HY-115778 UNC3133 Inhibitor / Unkown
HY-162406 UNC8969 / Unkown
HY-169208 MerTK-IN-1 Inhibitor / Unkown
HY-173400 UNC8212 Inhibitor / Unkown
HY-174160 MerTK-IN-2 / Unkown
HY-176482 MerTK-IN-3 Inhibitor / Unkown
HY-101549A MRX-2843 hydrochloride Inhibitor / Unkown
HY-RS23113 Mertk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mertk NCBI NCBI:10461