HDAC-IN-79
Based on 1 publication(s) in Google Scholar
HDAC-IN-79 (compound 4) is an orally active dual xanthine oxidase-HDAC inhibitor (Xanthine oxidase: IC50=6.6 nM; HDAC1: IC50=134 nM; HDAC2: IC50=284 nM; HDAC3: IC50=173 nM; HDAC6: IC50=1.32 nM;), with significant in vivo anti-hyperuricemia and anti-tumor activities. HDAC-IN-79 is the most potent cell growth inhibitor (IC50=0.706 μM) of leukemia HL60 cells, induces apoptosis and autophagy, and can regulate the expression levels of signature biomarkers associated with intracellular HDAC inhibition.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C23H30N4O4S
- 분자량:458.57
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-79
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Biological Activity
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HDAC1 134 nM (IC50) |
HDAC2 284 nM (IC50) |
HDAC3 173 nM (IC50) |
HDAC6 1.32 nM (IC50) |
Chemical Information
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분자량 458.57
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화학식 C23H30N4O4S
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SMILES
CC(C)COC1=CC=C(C2=NC(C)=C(C(NCCCCCCC(NO)=O)=O)S2)C=C1C#N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-79 Related Classifications
HY-162910 Related Classifications
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