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Imipenem

(Synonyms: N-Formimidoyl thienamycin; MK0787)
38 Cited Publications
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Based on 38 publication(s) in Google Scholar

Imipenem (MK0787), a stable crystalline derivative of thienamycin, is an antibiotic and has the excellent activity against a broad range of gram-positive and gram-negative aerobic and anaerobic bacteria. Imipenem can be used for the research of carbapenem-nonsusceptible and P. aeruginosa biofilm infections.

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  • Purity: 99.89%
  • CAS No.: 64221-86-9
  • 화학식: C12H17N3O4S
  • 분자량:299.35
  • 보관:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • Imipenem Chemical Structure
    Imipenem Chemical Structure
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
  • Experimental Validation Results for Imipenem
CAS No.: 64221-86-9
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  • Imipenem Chemical Structure
    Imipenem Chemical Structure
    1/16
  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Antimicrob Agents Chemother. 2025 Jul 2;69(7):e0024925. [Abstract]

    Customer Validation
     Numbers of organisms treated with 16× MIC NITD-916, 8 mg/L RFB or 16 mg/L IPM at 24 and 48 hours were significantly less than the drug-free control.

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]

    Customer Validation
     Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. The protein levels of Cit-H3 in the lungs were detected by western blot and analyzed by grayscale.

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]

    Customer Validation
     Combination of ATR and IMP effectively inhibits the formation of NETs. After CLP modeling, ATR was administered with Imipenem monohydrate (25 mg/kg, subcutaneously) at 6 and 18 h. Co-localization of Cit-H3, MPO and DAPI was observed by fluorescence microscopy and the level of NETs formation was analyzed (n = 4).

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]

    Customer Validation
     Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. HE staining and scoring of lung tissue, scale bar = 100 μm.

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]

    Customer Validation
     Combination of ATR and IMP alleviates lung injury by inhibiting NETs. Treatments were administered at 6 and 18 h post-CLP modeling with ATR, Imipenem monohydrate (25 mg/kg, subcutaneously), and DNase I. After 24 h, lung tissues were examined for pulmonary injury and NET expression. Co-localization of Cit-H3, MPO and DAPI in NET was observed using fluorescence microscopy

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2024 Aug 1:220:179-191. [Abstract]

    Customer Validation
     Imipenem monohydrate (1, 5, 10 μM) was pre-treated with neutrophils for 2 h, followed by stimulation with LPS (5 μg/mL) for 4 h. Cit-H3 was detected by western blot.

  • 1/16

    Imipenem purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575. [Abstract]

    Customer Validation
     Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

  • Imipenem