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Cat. No.: HY-187685

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L 696418

L 696418 is a MMP-3 inhibitor with a K_i value of 310 nM. L 696418 inhibits MMP-3 activity, thereby preventing the release of proteoglycans from cartilage. L 696418 reduces proteoglycan release in rabbit knee joints exposed to interleukin-1β (IL-1β). L 696418 can be used in research related to cartilage degradation.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 147485-09-4
화학식: C₂₅H₃₃N₃O₄
분자량:439.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

L 696418 Chemical Structure

CAS No.: 147485-09-4

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

MMP-3

All MMP Isoforms :

In Vivo

Intravenous administration of L 696418 inhibits proteoglycan release by approximately 50% in rabbit knee joints treated with intra-articular injection of human MMP-3 and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 147485-09-4
분자량 439.55
화학식 C₂₅H₃₃N₃O₄
SMILES

C[C@H](C(O)=O)N[C@H](C(N[C@@H](CC(C)C)C(NC1=CC=CC=C1)=O)=O)CCC2=CC=CC=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Esser CK, et al. Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. Journal of medicinal chemistry. 1997 Mar 14;40(6):1026-40.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References

상품명:
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수량:
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L 696418

All MMP Isoforms