LC-PDA-01
Based on 1 Customer Validation
LC-PDA-01 is a selective peroxiredoxin 1 (PRDX1) activator with an EC50 of 111.8 nM and a human KD of 123.2 nM. LC-PDA-01 inhibits the expression of pro-inflammatory cytokines IL-1β, IL-6 and TNF-α. LC-PDA-01 can be used in antioxidant/anti-inflammatory research.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- 화학식: C18H15Cl2N5O4
- 분자량:436.25
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- Protocol
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
In Vitro
LC-PDA-01 (100 μM; 3 h) significantly stabilizes endogenous PRDX1 protein in HEK-293T human embryonic kidney cells, as measured by cellular thermal shift assay[1].
LC-PDA-01 (20 μM) significantly suppresses LPS (HY-D1056)-induced expression of IL-1β, IL-6, and TNF-α mRNA in RAW 264.7 mouse macrophages[1].
LC-PDA-01 (Incubated to measure half-life of 381.6 min) shows excellent metabolic stability in mouse liver microsomes, with a half-life of 381.6 min and a hepatic extraction ratio of 13.7%[1].
LC-PDA-01 has low apparent permeability (Papp A→B = 0.06 × 10-6 cm/s) across Caco-2 monolayers, with a high efflux ratio of 5.23, suggesting potential P-gp-mediated active efflux[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
분자량 436.25
-
화학식 C18H15Cl2N5O4
-
SMILES
NC1=CC=C(C=C1)C[C@H](C(O)=O)NC(C2=CN(N=N2)C3=CC(Cl)=CC(Cl)=C3O)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
용액&용해도
In Vitro:
DMSO : 100 mg/mL (229.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2923 mL | 11.4613 mL | 22.9226 mL | 57.3066 mL |
| 5 mM | 0.4585 mL | 2.2923 mL | 4.5845 mL | 11.4613 mL | |
| 10 mM | 0.2292 mL | 1.1461 mL | 2.2923 mL | 5.7307 mL | |
| 15 mM | 0.1528 mL | 0.7641 mL | 1.5282 mL | 3.8204 mL | |
| 20 mM | 0.1146 mL | 0.5731 mL | 1.1461 mL | 2.8653 mL | |
| 25 mM | 0.0917 mL | 0.4585 mL | 0.9169 mL | 2.2923 mL | |
| 30 mM | 0.0764 mL | 0.3820 mL | 0.7641 mL | 1.9102 mL | |
| 40 mM | 0.0573 mL | 0.2865 mL | 0.5731 mL | 1.4327 mL | |
| 50 mM | 0.0458 mL | 0.2292 mL | 0.4585 mL | 1.1461 mL | |
| 60 mM | 0.0382 mL | 0.1910 mL | 0.3820 mL | 0.9551 mL | |
| 80 mM | 0.0287 mL | 0.1433 mL | 0.2865 mL | 0.7163 mL | |
| 100 mM | 0.0229 mL | 0.1146 mL | 0.2292 mL | 0.5731 mL |
LC-PDA-01 Related Classifications
HY-182308 Related Classifications
Powered by Bioz