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Cat. No.: HY-13506G

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M344 (GMP)

(Synonyms: D 237 (GMP); MS 344 (GMP))

고객리뷰

Based on 1 Customer Validation

M344 (GMP) (D 237) (GMP) is the GMP level of M344 (HY-13506). GMP level of small molecules can be used as auxiliary reagents in cell therapy. M344 is a kind of histone acetylation enzyme inhibitor.

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CAS No.: 251456-60-7
화학식: C₁₆H₂₅N₃O₃
분자량:307.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

M344 (GMP) Chemical Structure

CAS No.: 251456-60-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

M344 (GMP) (D 237) (GMP) is the GMP level of M344 (HY-13506). GMP level of small molecules can be used as auxiliary reagents in cell therapy. M344 is a kind of histone acetylation enzyme inhibitor^[1].

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	2.3 μM Compound: 23	Concentration required to inhibit the epidermoid A431 cell growth by 50%, P53 status of cell line used was wild-type. Concentration required to inhibit the epidermoid A431 cell growth by 50%, P53 status of cell line used was wild-type.	[PMID: 11831887]
A549	IC₅₀	0.8 μM Compound: 23	Concentration required to inhibit the lung A549 cell growth by 50%,P53 status of cell line used was wild-type. Concentration required to inhibit the lung A549 cell growth by 50%,P53 status of cell line used was wild-type.	[PMID: 11831887]
HCT-116	IC₅₀	0.2 μM Compound: 23	Concentration required to inhibit the colon HCT116 cell growth by 50%,P53 status of cell line used was wild-type. Concentration required to inhibit the colon HCT116 cell growth by 50%,P53 status of cell line used was wild-type.	[PMID: 11831887]
HCT-116	IC₅₀	0.21 μM Compound: 23	Concentration required to inhibit the HCT116 cell growth by 50%. Concentration required to inhibit the HCT116 cell growth by 50%.	[PMID: 11831887]
LS174T	IC₅₀	1.5 μM Compound: 23	Concentration required to inhibit the colon LS 174T cell growth by 50%,P53 status of cell line used was mutant-type. Concentration required to inhibit the colon LS 174T cell growth by 50%,P53 status of cell line used was mutant-type.	[PMID: 11831887]
NCI-H1299	IC₅₀	3.9 μM Compound: 23	Concentration required to inhibit the lung H1299 cell growth by 50%,P53 status of cell line used was wild-type. Concentration required to inhibit the lung H1299 cell growth by 50%,P53 status of cell line used was wild-type.	[PMID: 11831887]
SW-620	IC₅₀	0.7 μM Compound: 23	Concentration required to inhibit the colon SW 620 cell growth by 50%,P53 status of cell line used was mutant-type. Concentration required to inhibit the colon SW 620 cell growth by 50%,P53 status of cell line used was mutant-type.	[PMID: 11831887]
T-24	IC₅₀	3.8 μM Compound: 23	Concentration required to inhibit the bladder T24 cell growth by 50%,P53 status of cell line used was wild-type. Concentration required to inhibit the bladder T24 cell growth by 50%,P53 status of cell line used was wild-type.	[PMID: 11831887]

Chemical Information

CAS No. 251456-60-7
Appearance Solid
분자량 307.39
화학식 C₁₆H₂₅N₃O₃
Color White to off-white
SMILES

O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1
Synonyms

D 237 (GMP); MS 344 (GMP)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Volmar C H, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer’s disease genes and improving memory[J]. Proceedings of the National Academy of Sciences, 2017, 114(43): E9135-E9144. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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M344 (GMP)

All HDAC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

M344 (GMP) Related Classifications

HY-13506G Related Classifications