Moracin G
Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer.
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- CAS No.: 73338-86-0
- 화학식: C19H16O4
- 분자량:308.33
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Akt1 |
COX-2 |
Moracin G meets the pharmacokinetic criteria for active ingredients, with an oral bioavailability of 75.78% and a drug-likeness score of 0.42[1].
Moracin G is a key active component in mulberry leaves that alleviates periodontitis, and it interacts with 37 different human targets associated with periodontitis. The top 10 key targets are IL-6, ALB, TNF, VEGFA, AKT1, TP53, PTGS2, EGF, MMP9, and IL-10, among which the binding affinity with AKT1 is -10.7 kcal/mol[1].
Moracin G exhibits favorable in silico ADMET properties, including high gastrointestinal absorption, low blood-brain barrier permeability, and no predicted toxicity, rendering it a viable candidate for further development[2].
Moracin G is predicted to have a high probability of acting as a kinase inhibitor, antineoplastic agent, apoptosis agonist, and antineoplastic agent against breast cancer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 73338-86-0
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분자량 308.33
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화학식 C19H16O4
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SMILES
OC1=CC(O)=CC(C2=CC(C=CC3=C4CC=C(C)CO3)=C4O2)=C1
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Wu Z, et al. Exploring the pharmacological components and effective mechanism of Mori Folium against periodontitis using network pharmacology and molecular docking. Arch Oral Biol. 2022;139:105391. [Content Brief]
[2]. Prasad P, et al. Computational identification of Moracin G and Isolonchocarpin as potent MELK inhibitors for anticancer drug discovery. Sci Rep. 2025;16(1):397. Published 2025 Dec 6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Moracin G Related Classifications
HY-N17632 Related Classifications
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