country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-182429

Copy Link Print Information

NB-533

NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC₅₀ of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC₅₀ of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ₄₀ release. NB-533 reduces brain levels of APP metabolite C99 and Aβ₄₀ in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1146544-18-4
화학식: C₃₃H₅₅N₃O₄
분자량:557.81

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NB-533 Chemical Structure

CAS No.: 1146544-18-4

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

BACE1

0.002 μM (IC₅₀)

Cathepsin D

0.001 μM (IC₅₀)

All Beta-secretase Isoforms :

BACE1
BACE2

All Cathepsin Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	24 μM Compound: 14, NB-533	Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregation Inhibition of BACE1 expressed in CHO cells expressing human recombinant APP assessed as amyloid beta40 aggregation	[PMID: 19195887]

In Vitro

NB-533 potently inhibits human BACE-1 enzyme with an IC₅₀ of 0.002 μM^[1].
NB-533 inhibits Aβ₄₀ release from human APP-transfected CHO cells with an IC₅₀ of 0.024 μM^[1].
NB-533 inhibits human cathepsin D with an IC₅₀ of 0.001 μM^[1].
NB-533 has an efflux ratio (BA/AB) of 9.4 in MDCK mdr1a cells, showing reduced P-glycoprotein susceptibility^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NB-533 (100 μmol/kg; p.o.; double-dose at 0 and 3 h) significantly reduces forebrain C99 by 20% and CSF Aβ₄₀ by 26% in APP51/16 transgenic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

APP51/16 transgenic mice (expressing wild-type human APP under a brain-specific promoter)^[1]
Dosage:

100 μmol/kg
Administration:

p.o.; at 0 and 3 hours
Result:

Reached brain levels of 0.53 μmol/kg, with no detectable effect on measured endpoints.
Reached brain levels of 1.5 μmol/kg, resulting in a significant 20% reduction in forebrain C99 and a significant 26% reduction in CSF Aβ₄₀; no significant reduction in brain Aβ₄₀ was observed.

Chemical Information

CAS No. 1146544-18-4
분자량 557.81
화학식 C₃₃H₅₅N₃O₄
SMILES

O[C@@H]([C@@]1([H])NC([C@@H](N(C(CCCCCCCC[C@H](C1)C)=O)C)C)=O)CN[C@@H]2C3=CC(C(C)C)=CC=C3OC(C)(C2)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Machauer R, et al. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg Med Chem Lett. 2009;19(5):1366-1370. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NB-533

All Beta-secretase Isoforms

All Cathepsin Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NB-533 Related Classifications

HY-182429 Related Classifications