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Cat. No.: HY-184075S

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Nomelcitinib

Nomelcitinib is a TYK2 inhibitor that modulates the IL23 signaling pathway. Nomelcitinib is used for research on multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, psoriasis, psoriatic arthritis, Crohn's disease, Sjögren's syndrome, and scleroderma.

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CAS No.: 2794195-73-4
화학식: C₁₆H₁₄D₃ClN₆O₄S
분자량:427.88

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nomelcitinib Chemical Structure

CAS No.: 2794195-73-4

사이즈

가격

재고

수량

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Tyk2

IL-23

All JAK Isoforms :

All Interleukin Related Isoforms :

In Vitro

Nomelcitinib (Compound 52) potently inhibits IL-23 pathway activity in HEK-Blue IL-23 reporter cells with an IC₅₀ of 2.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2794195-73-4
분자량 427.88
화학식 C₁₆H₁₄D₃ClN₆O₄S
SMILES

[2H]C([2H])([2H])NC(C(N=NC(NC(C1CC1)=O)=C2)=C2NC3=C(C=C(C=N3)Cl)S(C)(=O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Xing DAI, et al. Heteroaryl compounds, preparation methods and uses thereof. WO2022135430A1. 2021-12-22.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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Nomelcitinib

All JAK Isoforms

All Interleukin Related Isoforms