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Cat. No.: HY-P11649

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NYLTHRQ

NYLTHRQ is a peptide. NYLTHRQ specifically blocks the interaction between sVEGFR1-i13 and β1 integrin, and inhibits the activation of VEGFR1 and VEGFR2. NYLTHRQ inhibits cancer cell proliferation. NYLTHRQ can be used in the research of tumors such as lung squamous cell carcinoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1004284-41-6
화학식: C₄₀H₆₂N₁₄O₁₂
분자량:931.01

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NYLTHRQ Chemical Structure

CAS No.: 1004284-41-6

사이즈

가격

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수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

VEGFR1

VEGFR2

All Integrin Isoforms :

All VEGFR Isoforms :

In Vitro

NYLTHRQ (10 μg/mL; 72 h) specifically blocks the interaction between sVEGFR1-i13 and β1 integrin in MGH7 cells, inhibits VEGFR activation, and reduces cell proliferation activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MGH7 squamous cell lung carcinoma (SQLC) cells
Concentration:

10 μg/mL
Incubation Time:

72 h
Result:

Prevented the activation of VEGFR1 (Tyr1213) and VEGFR2 (Tyr1214) proteins.
Blocked the increased cell proliferation induced by sVEGFR1-i13-containing conditioned supernatants.

Chemical Information

CAS No. 1004284-41-6
분자량 931.01
화학식 C₄₀H₆₂N₁₄O₁₂
Sequence

Asn-Tyr-Leu-Thr-His-Arg-Gln
Sequence Shortening

NYLTHRQ
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (261 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abou Faycal C, et al. The sVEGFR1-i13 splice variant regulates a β1 integrin/VEGFR autocrine loop involved in the progression and the response to anti-angiogenic therapies of squamous cell lung carcinoma. Br J Cancer. 2018;118(12):1596-1608. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NYLTHRQ

All Integrin Isoforms

All VEGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NYLTHRQ Related Classifications

HY-P11649 Related Classifications