ONC1-13B
ONC1-13B is a potent androgen receptor (AR) antagonist with the activity of effectively inhibiting PSA expression in prostate cancer cells. ONC1-13B can effectively inhibit PSA expression and prostate cancer cell proliferation under DHT stimulation. ONC1-13B exerts its anti-tumor effect by preventing androgen from binding to AR and its nuclear translocation.
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- CAS No.: 1351185-54-0
- 화학식: C22H16F4N4O3S
- 분자량:492.45
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
79.2 nM
Compound: (R)-6
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Antiproliferative activity against human LNCAP cells after 3 days
Antiproliferative activity against human LNCAP cells after 3 days
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[PMID: 26046313] |
Chemical Information
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CAS No. 1351185-54-0
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분자량 492.45
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화학식 C22H16F4N4O3S
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SMILES
O=C1[C@]2(CCOC2)N(C3=CC(F)=C(C=C3)C(NC)=O)C(N1C4=CC(C(F)(F)F)=C(C=C4)C#N)=S
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ONC1-13B Related Classifications
HY-114246 Related Classifications
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