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PD 169316

28 Cited Publications
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Based on 28 publication(s) in Google Scholar

PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71.

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  • Purity: 99.07%
  • CAS No.: 152121-53-4
  • 화학식: C20H13FN4O2
  • 분자량:360.34
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • PD 169316 Chemical Structure
    PD 169316 Chemical Structure
  • Experimental Validation Results for PD 169316
  • Experimental Validation Results for PD 169316
  • Experimental Validation Results for PD 169316
  • Experimental Validation Results for PD 169316
CAS No.: 152121-53-4
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All p38 MAPK Isoforms

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  • PD 169316 Chemical Structure
    PD 169316 Chemical Structure
    1/16
  • 1/16

    PD 169316 purchased from MedChemExpress. Usage Cited in: Oncol Lett. 2018 Jan;15(1):235-242. [Abstract]

    Customer Validation
     Cells are treated with 15 and 20 μM Lapatinib for 24 h, the expression of p AKT, AKT, p p38 MAPK, p38 MAPK, p JNK, and JNK are measured by western blotting. Quantification analysis of western blotting, β actin is served as a control. D: 1 DMSO; 2 PD169316; 3 15 μM Lapatinib; 4 PD169316+15 μM Lapatinib).

  • 1/16

    PD 169316 purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2017 Dec;38(6):3668-3676. [Abstract]

    Customer Validation
     Western blot analysis evaluated p-p38, p38, LC3 and quantification of LC3-II in untreated (control), treated with the p38 inhibitor PD169316, cisplatin, and both these agents in MDA-MB-231 cells.

  • 1/16

    PD 169316 purchased from MedChemExpress. Usage Cited in: Int J Med Sci. 2016 Jul 18;13(8):611-9. [Abstract]

    Customer Validation
     PD169316 (10 μM) inhibits the effects of all-trans retinoic acid(ATRA) on nuclear localization signal retinoic acid receptor alpha (NLS-RARα)-overexpressed NB4 cells incluing an increase of the expressions of p-p38α, C/EBPβ and CD11b.

  • 1/16

    PD 169316 purchased from MedChemExpress. Usage Cited in: Chinese Journal of Cell Biology. 2016, 38(7): 770–776

    Customer Validation
     The protein levels of Bax and Bcl-2 detected by Western blot. PD169316 decreases EGCG-mediated increases in Bax protein expression.

  • PD 169316