PLN-1474
Based on 1 Customer Validation
PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.
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- Purity: 99.35%
- CAS No.: 2408065-32-5
- 화학식: C24H37N3O4
- 분자량:431.57
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
IC50: ＜50 nM (ανβ1), ＜50 nM (ανβ6)[1]
PLN-1474 inhibits ανβ1 and ανβ6 with IC50s of <50 nM by solid phase assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2408065-32-5
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Appearance Solid
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분자량 431.57
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화학식 C24H37N3O4
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Color White to light yellow
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SMILES
O=C(O)[C@H](CCCCCCCC1=CC=C2C(N1)=NCCC2)NC(C3(C)CCOCC3)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 70 mg/mL (162.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3171 mL | 11.5856 mL | 23.1712 mL | 57.9280 mL |
| 5 mM | 0.4634 mL | 2.3171 mL | 4.6342 mL | 11.5856 mL | |
| 10 mM | 0.2317 mL | 1.1586 mL | 2.3171 mL | 5.7928 mL | |
| 15 mM | 0.1545 mL | 0.7724 mL | 1.5447 mL | 3.8619 mL | |
| 20 mM | 0.1159 mL | 0.5793 mL | 1.1586 mL | 2.8964 mL | |
| 25 mM | 0.0927 mL | 0.4634 mL | 0.9268 mL | 2.3171 mL | |
| 30 mM | 0.0772 mL | 0.3862 mL | 0.7724 mL | 1.9309 mL | |
| 40 mM | 0.0579 mL | 0.2896 mL | 0.5793 mL | 1.4482 mL | |
| 50 mM | 0.0463 mL | 0.2317 mL | 0.4634 mL | 1.1586 mL | |
| 60 mM | 0.0386 mL | 0.1931 mL | 0.3862 mL | 0.9655 mL | |
| 80 mM | 0.0290 mL | 0.1448 mL | 0.2896 mL | 0.7241 mL | |
| 100 mM | 0.0232 mL | 0.1159 mL | 0.2317 mL | 0.5793 mL |
PLN-1474 Related Classifications
HY-47888 Related Classifications
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