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Cat. No.: HY-P11877

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PLSRTLSVAAK

PLSRTLSVAAK is a peptide substrate used for the detection of PKC phosphorylation activity, and can be applied to in vitro kinase activity assays of PKCδ.

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CAS No.: 105802-83-3
화학식: C₅₀H₉₁N₁₅O₁₅
분자량:1142.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

PLSRTLSVAAK Chemical Structure

CAS No.: 105802-83-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PLSRTLSVAAK is a peptide substrate used for the detection of PKC phosphorylation activity, and can be applied to in vitro kinase activity assays of PKCδ^[1]^[2].

IC₅₀ & Target^[1]

PKCδ

All PKC Isoforms :

In Vitro

PLSRTLSVAAK (0.4 μg/μl; 30 min at 30°C) incubation of membrane-bound PKC preparations from BALB/c mouse hippocampal slices results in measurable substrate phosphorylation, while identical incubation with preparations from C57BL/6N mouse hippocampal slices shows no detectable phosphorylation^[1].
PLSRTLSVAAK kinase-active c-Abl activates GST-PKCδ, which then increases phosphorylation of the PLSRTLSVAAK peptide substrate by a mean fold-increase of ~5 relative to PKCδ alone^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 105802-83-3
분자량 1142.35
화학식 C₅₀H₉₁N₁₅O₁₅
Sequence

Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys
Sequence Shortening

PLSRTLSVAAK
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Blank T, Nijholt I, Grammatopoulos D K, et al. Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning[J]. Journal of Neuroscience, 2003, 23(2): 700-707. [Content Brief]

[2]. Yuan Z M, Utsugisawa T, Ishiko T, et al. Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation[J]. Oncogene, 1998, 16 [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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PLSRTLSVAAK

All PKC Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PLSRTLSVAAK Related Classifications

HY-P11877 Related Classifications