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Cat. No.: HY-179243

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S3D5

S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM). S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the p53 pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS). S3D5 can be used for the study of hepatocellular carcinoma.
(Pink: STAT3 ligand (HY-163526); Blue: Cereblon ligand (HY-10984); Black: linker (HY-130447)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3033746-21-0
화학식: C₄₁H₄₅F₅N₆O₁₃S
분자량:956.89

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

S3D5 Chemical Structure

CAS No.: 3033746-21-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

S3D5 is a highly efficient and selective PROTAC degrader targeting STAT3 (KD = 4.35 μM). S3D5 induces degradation of STAT3 in HepG2 cells without significant effects on other STAT proteins. S3D5 exhibits good anti-hepatocellular carcinoma cell proliferation activity, which can be explained by activating the p53 pathway. S3D5 degradation of the STAT3 protein is mediated by the ubiquitin–proteasome system (UPS). S3D5 can be used for the study of hepatocellular carcinoma^[1]. (Pink: STAT3 ligand (HY-163526); Blue: Cereblon ligand (HY-10984); Black: linker (HY-130447)).

IC₅₀ & Target

STAT3

4.35 μM (Kd)

All PROTACs Isoforms :

All STAT Isoforms :

In Vitro

S3D5 (4-20 μM, 96 h) shows optimal activity in HepG2 cells, with an IC₅₀ value of 8.53 μM^[1].
S3D5 (0.1-2 μM, 24-48 h) can induce STAT3 degradation in HepG2 cells (DC₅₀ = 110 nM), and have little effect at any concentration on STAT1, STAT2, STAT4, STAT5, and STAT6 proteins^[1].
S3D5 (2.5-20 μM, 96 h) inhibits the growth of HepG2 cells in a dose-dependent manner and inhibits the proliferation of 293T cells at 5 μM^[1].
S3D5 (1-20 μM, 14 days) leads to a significant reduction in both the number and size of HepG2 cell colonies compared to the control^[1].
S3D5 (5μM, 24-72 h) can inhibit the proliferation, migration and invasion of HepG2 cells^[1].
S3D5 (0.1-2 μM, 48 h) dose-dependently upregulates p53 and p21 protein levels, while downregulates STAT3 protein levels in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

0.1 μM, 0.2 μM, 0.5 μM
Incubation Time:

24 h
Result:

Induced STAT3 degradation in HepG2 cells.

Cell Proliferation Assay^[1]

Cell Line:

HepG2 cells
Concentration:

1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM
Incubation Time:

14 days
Result:

Led to a significant reduction in both the number and size of HepG2 cells.

Cell Invasion Assay^[1]

Cell Line:

HepG2 cells
Concentration:

5 μM
Incubation Time:

24 h
Result:

Significantly inhibited the invasive ability of HepG2 cells.

Cell Migration Assay ^[1]

Cell Line:

HepG2 cells
Concentration:

5 μM
Incubation Time:

72 h
Result:

Significantly inhibited the migration ability of HepG2 cells.

Chemical Information

CAS No. 3033746-21-0
분자량 956.89
화학식 C₄₁H₄₅F₅N₆O₁₃S
SMILES

CN(S(=O)(C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC(NC2=CC=C(C=C2)C(NCCOCCOCCOCCOCCOCCNC3=C4C(C(N(C5C(NC(CC5)=O)=O)C4=O)=O)=CC=C3)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang K, et al. Discovery of a potent and selective PROTAC degrader for STAT3. RSC Med Chem. 2025 Jul 31. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

S3D5

All PROTACs Isoforms

All STAT Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

S3D5 Related Classifications

HY-179243 Related Classifications

Bioz

Keywords

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