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Cat. No.: HY-111906

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SCYX-6759

SCYX-6759 is an orally active, blood-brain barrier permeable anti-T. brucei agent. SCYX-6759 inhibits cytochrome P450 (IC₅₀s: 30.3, 30.6, 47.4 μM for 2D6, 2C9, 2C19, respectively.) SCYX-6759 exhibits potent activity against T. b. brucei 427, T. b. rhodesiense STIB900, and T. b. gambiense STIB930, with IC₅₀s of 0.07, 0.038 and 0.030 μg/mL, respectively.

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CAS No.: 1222509-12-7
화학식: C₁₅H₁₀BF₄NO₃
분자량:339.05

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SCYX-6759 Chemical Structure

CAS No.: 1222509-12-7

사이즈

가격

재고

수량

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CYP2D6

30.3 μM (IC₅₀)

CYP2C9

30.6 μM (IC₅₀)

CYP2C19

47.4 μM (IC₅₀)

All Cytochrome P450 Isoforms :

All Parasite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	>64 μM Compound: 3; SCYX-6759	Cytotoxicity against human MRC5 cells measured after 3 days by resazurin staining based fluorometric analysis Cytotoxicity against human MRC5 cells measured after 3 days by resazurin staining based fluorometric analysis	[PMID: 34711050]
PBMC	IC₅₀	13 μM Compound: 1L	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TNFalpha release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay	[PMID: 24075731]
PBMC	IC₅₀	3.2 μM Compound: 1L	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-1beta release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay	[PMID: 24075731]
PBMC	IC₅₀	5.6 μM Compound: 1L	Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced IL-6 release incubated for 15 mins prior to LPS-challenge measured after 24 hrs by HTRF assay	[PMID: 24075731]
Peritoneal macrophage	CC₅₀	>64 μM Compound: 3; SCYX-6759	Cytotoxicity against mouse primary peritoneal macrophages measured after 3 days by resazurin staining based fluorometric analysis Cytotoxicity against mouse primary peritoneal macrophages measured after 3 days by resazurin staining based fluorometric analysis	[PMID: 34711050]

Chemical Information

CAS No. 1222509-12-7
분자량 339.05
화학식 C₁₅H₁₀BF₄NO₃
SMILES

O=C(C1=CC=C(C=C1C(F)(F)F)F)NC2=CC=C3C(B(OC3)O)=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nare B, et al. Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis. Antimicrob Agents Chemother. 2010 Oct;54(10):4379-88. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SCYX-6759

All Cytochrome P450 Isoforms

All Parasite Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SCYX-6759 Related Classifications

HY-111906 Related Classifications