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Cat. No.: HY-105028S

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Tenidap-d₃

Name: Tenidap-d3
Brand: MedChemExpress
SKU: HY-105028S
Availability: PreOrder

(Synonyms: CP-66248-d₃)

Tenidap-d₃ (CP-66248-d₃) is the deuterated-labeled Tenidap (CP-66248) (HY-105028). Tenidap (CP-66248) is an orally active cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor. Tenidap exerts anti-inflammatory and chondroprotective effects by downregulating IL-1 receptor expression, reducing the release of pro-inflammatory cytokines, and inhibiting metalloproteinase and acute-phase protein production, while also inhibiting SLC26A3-mediated chloride transport and the pH and membrane potential changes associated with sperm capacitation. Tenidap attenuates carrageenan-induced paw edema and acetic acid-induced writhing, and induces gastric ulcers in a dose-dependent manner, and can be used for research on rheumatoid arthritis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 142741-60-4
화학식: C₁₄H₆D₃ClN₂O₃S
분자량:323.77

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Tenidap-d₃ Chemical Structure

CAS No.: 142741-60-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[5]^[2]

COX-1

2.56 μM (IC₅₀)

COX-2

8.4 μM (IC₅₀)

5-LOX

36.70 μM (IC₅₀)

IL-1

All COX Isoforms :

All Lipoxygenase Isoforms :

All Interleukin Related Isoforms :

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 142741-60-4
Unlabeled CAS 120210-48-2
분자량 323.77
화학식 C₁₄H₆D₃ClN₂O₃S
SMILES

O/C(C1=C([2H])C([2H])=C([2H])S1)=C2C3=C(C=CC(Cl)=C3)N(C(N)=O)C/2=O
Synonyms

CP-66248-d₃
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Blackburn, et al. (1995), Tenidap in rheumatoid arthritis a 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis & Rheumatism, 38: 1447-1456.

[2]. Breedveld F, et al. Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. Scandinavian journal of rheumatology. Supplement. 1994;100:31-44. [Content Brief]

[3]. Julio C, et al. Participation of the Cl−/HCO3− Exchangers SLC26A3 and SLC26A6, the Cl− Channel CFTR, and the Regulatory Factor SLC9A3R1 in Mouse Sperm Capacitation, Biology of Reproduction, Volume 86, Issue 1, 1 January 2012, 14, 1-14.

[4]. Yi Liu, et al. Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3, European Journal of Pharmacology, Volume 435, Issues 2-3, 2002, Pages 153-160, ISSN 0014-2999.

[5]. Lai Y, et al. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors. Bioorganic & medicinal chemistry letters. 2010 Dec 15;20(24):7349-53. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- 신청
Chemical Information
순도&문서
References

상품명:
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Tenidap-d₃

All COX Isoforms

All Lipoxygenase Isoforms

All Interleukin Related Isoforms

Biological Activity

제품 설명

IC₅₀ & Target

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Bioz

Keywords

Your Recently Viewed Products

Tenidap-d3

All COX Isoforms

All Lipoxygenase Isoforms

All Interleukin Related Isoforms

Biological Activity

제품 설명

IC50 & Target

신청

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Tenidap-d3 Related Classifications

HY-105028S Related Classifications

Bioz

Keywords

Your Recently Viewed Products

Tenidap-d₃

IC₅₀ & Target

Tenidap-d₃ Related Classifications