TGF-8027
TGF-8027 is a selective 5-HT2A agonist that can cross the blood-brain barrier. TGF-8027 exhibits EC50s of 3.3 nM, 160 nM and 7600 nM against human 5-HT2A, 5-HT2C and 5-HT2B and exhibits EC50s against mouse 5-HT2A and mouse 5-HT2C of 14 and 210 nM. TGF-8027 can induce a head-shaking response in mice. TGF-8027 can be used to study diseases that target the 5-HT2A receptor (such as depression).
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- 화학식: C19H22N2O3
- 분자량:326.39
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All 5-HT Receptor Isoforms
More
Biological Activity
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5-HT2A Receptor 3.3 nM (EC50) |
5-HT2C Receptor 160 nM (EC50) |
5-HT2B Receptor 7600 nM (EC50) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Head-twitch response (HTR) model established in C57BL/6J mice[1]
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Dosage:0.4, 1.33, 4, 13.33 and 40 mg/kg
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Administration:Subcutaneous injection (s.c.), single dose
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Result:Induced a head-shaking response in mice in a dose-dependent manner.
Chemical Information
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분자량 326.39
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화학식 C19H22N2O3
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SMILES
COC1=C(CCNC(C)C2=CC=CC=C2O)C=C(OC)C(C#N)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TGF-8027 Related Classifications
HY-178760 Related Classifications
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