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U-73122

101 Cited Publications
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Based on 101 publication(s) in Google Scholar

U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.

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  • Purity: 98.28%
  • CAS No.: 112648-68-7
  • 화학식: C29H40N2O3
  • 분자량:464.64
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • U-73122 Chemical Structure
    U-73122 Chemical Structure
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
  • Experimental Validation Results for U-73122
CAS No.: 112648-68-7
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WBBio/Physico-chemical AssayRT-PCRCell Proliferation/Viability Assay
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  • Cell Proliferation/Viability Assay
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All Phospholipase Isoforms

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All Lipoxygenase Isoforms

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  • U-73122 Chemical Structure
    U-73122 Chemical Structure
    1/16
  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Aug;15(8):4078-4095. [Abstract]

    Customer Validation
     RAW264.7 cells (with or without U73122 (10 μmol/L), 2-APB (50 μmol/L), and BAPTM-AM (10 μmol/L) pretreatment for 30 min) were stimulated with LPS for 4 h. The levels of pJAK2 and pSTAT3Tyr705 as well as IL-1β expression were determined by Western blotting.

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Aug;15(8):4078-4095. [Abstract]

    Customer Validation
     RAW264.7 cells (with or without U73122 (10 μmol/L), 2-APB (50 μmol/L), and BAPTM-AM (10 μmol/L) pretreatment for 30 min) were stimulated with LPS for 4 h. The levels of pJAK2 and pSTAT3Tyr705 as well as IL-1β expression were determined by Q-PCR.

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 22;11(34):eadt9645. [Abstract]

    Customer Validation
     Intestinal ILCs were cultured with TDCA (10 μM), Ca2+ inhibitor (U-73122, 1 μM, overnight), or ROCK inhibitor [(S)-H-1152, 1 μM], and, then, mRNA expression of Cd69 and S1pr1 was analyzed.

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Cell Death Differ. 2022 Jul;29(7):1318-1334. [Abstract]

    Customer Validation
     S2D HeLa cells die in the presence of the PLC inhibitor U73122 (1-2 μM, 0-8 h).

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Redox Biol. 2021 Oct:46:102115 [Abstract]

    Customer Validation
     Mesenteric artery response to Ang II in the presence of PLC inhibitor U73122 (10 μM, remained present throughout the entire experiment).

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: Oncotarget. 2017 Nov 22;8(65):109135-109150. [Abstract]

    Customer Validation
     MCF-7 cells are pretreated with the indicated chemical inhibitors for 30min, followed by 15 min treatment with RA (20 μM) + EPA (80 μM).Cell extracts are prepared and subjected to western blotting analysis.

  • 1/16

    U-73122 purchased from MedChemExpress. Usage Cited in: J Mol Neurosci. 2015 Aug;56(4):848-57. [Abstract]

    Customer Validation
     Effect of LXA4 on astrocyte viability. Cell viability is measured by MTT reduction assay. Results are expressed as the percentage of MTT reduction normalized to the control group (100 %). The MTT reduction is reduced by OGDR, but is significantly increased by LXA4. The effect is not antagonized by Boc2, but partly reversed by U73122 and T0070907.

  • U-73122