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Cat. No.: HY-P99201

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Biologically Validated

Zilovertamab

Name: Zilovertamab
Brand: MedChemExpress
SKU: HY-P99201
Price: 300.00 USD
Availability: InStock
Rating: 5 (2 reviews)

(Synonyms: UC-961; Cirmtuzumab)

2 Cited Publications

고객리뷰

Based on 2 publication(s) in Google Scholar

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 98.21%
CAS No.: 2485779-13-1
분자량:145.12 kDa

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zilovertamab Chemical Structure

CAS No.: 2485779-13-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
- Verified Bioactivity
Chemical Information
Publications (2)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Wnt5A

All ROR Isoforms :

All Wnt Isoforms :

In Vitro

Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation^[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

25 and 50 µg/mL
Incubation Time:

72 hours
Result:

Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

50 µg/mL
Incubation Time:

72 hours
Result:

Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

4919 [NCBI]

Accession

Q01973

Target

ROR1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC₅₀ for this effect is 3.078 ng/mL.

Chemical Information

CAS No. 2485779-13-1
Appearance Liquid
분자량 145.12 kDa
Color Colorless to light yellow
SMILES

[Zilovertamab]
Synonyms

UC-961; Cirmtuzumab
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mol Ther

Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy. [Abstract]

2025 Dec 2:S1525-0016(25)00959-1. PMID: 41338184
Research Square Preprint

2024 Dec 02.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Liu D, et, al. The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells. Pharmaceutics. 2022 Apr 11;14(4):837. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Zilovertamab

2 Cited Publications

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Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- 신청
- Biological Activity
Chemical Information
Publications (2)
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Zilovertamab

Publications Citing Use of MedChemExpress (MCE) Zilovertamab

All ROR Isoforms

All Wnt Isoforms