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Methoxyflurane 

Cat. No.: HY-B0718
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Methoxyflurane is a halogenated volatile anaesthetic agent with potent analgesic effects at sub-anaesthetic doses. Methoxyflurane widely used as an open-circuit anaesthetic in small laboratory animals for several decades. Methoxyflurane has the risk of nephrotoxicity.

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Methoxyflurane Chemical Structure

Methoxyflurane Chemical Structure

CAS No. : 76-38-0

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Description

Methoxyflurane is a halogenated volatile anaesthetic agent with potent analgesic effects at sub-anaesthetic doses. Methoxyflurane widely used as an open-circuit anaesthetic in small laboratory animals for several decades. Methoxyflurane has the risk of nephrotoxicity[1][2].

In Vitro

Methoxyflurane is delivered via a hand-held inhaler[3].

In Vivo

The developmental toxicity of trace, subanesthetic, and anesthetic exposure to Methoxyflurane is examined in Swiss/ICR mice. No adverse effects on reproduction or fetal development were demonstrated following exposure to trace (2 ppm) and subanesthetic (60 ppm) concentrations of Methoxyflurane for 4 hours daily on days 6 through 15 of pregnancy. Exposure to an anesthetic concentration (2000 ppm; 0.2%) for the same period resulted in decreased fetal weight, decreased ossification, and delayed renal maturation. Additionally, the incidence of minor skeletal anomalies was increased. It is concluded that gestational exposure of mice to trace of subanesthetic concentrations of Methoxyflurane does not result in reproductive loss or morphologic abnormalities in their offspring[4].

Molecular Weight

164.97

Formula

C₃H₄Cl₂F₂O

CAS No.

76-38-0

SMILES

COC(F)(F)C(Cl)Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

MethoxyfluraneOthersanaestheticagentdosenephrotoxicityhalogenatedsupplierInhibitorinhibitorinhibit

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Methoxyflurane
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