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Cat. No.: HY-134724

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MTH1 ligand 1

MTH1 ligand 1 is a target protein ligand for MTH1 and can be used to synthesize PROTAC aTAG 2139 (HY-161162).

For research use only. We do not sell to patients.

CAS No.: 2412986-35-5
Formula: C₂₃H₁₈N₄O₃
Molecular Weight:398.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

MTH1 ligand 1 Chemical Structure

CAS No.: 2412986-35-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

MTH1 ligand 1 is a target protein ligand for MTH1 and can be used to synthesize PROTAC aTAG 2139 (HY-161162)^[1].

IC₅₀ & Target

MTH1

All DNA/RNA Synthesis Isoforms :

All Ligands for E3 Ligase Isoforms :

In Vitro

MTH1 ligand 1 can be used to synthesize aTAG-based MTH1 fusion protein degrader aTAG 2139 (HY-161162) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412986-35-5
Molecular Weight 398.41
Formula C₂₃H₁₈N₄O₃
SMILES

O=C(C1=NC=C(C2=CC=C3N=CC(C(NC)=O)=C(NC4=CC=CC=C4)C3=C2)C=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gesine K. Veits, et al. Development of an AchillesTAG degradation system and its application to control CAR-T activity. Current Research in Chemical Biology Volume 1, 2021, 100010

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MTH1 ligand 1

All DNA/RNA Synthesis Isoforms

All Ligands for E3 Ligase Isoforms