Muscone
Based on 4 publication(s) in Google Scholar
Muscone is the main active monomer of traditional Chinese medicine musk. Muscone inhibits NF-κB and NLRP3 inflammasome activation. Muscone remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6), and ultimately improves cardiac function and survival rate.
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- Pureté : 98.0%
- CAS No.: 541-91-3
- Formule: C16H30O
- Masse moléculaire:238.41
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Muscone
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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RT-PCR
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WB
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Cell Migration/Invasion Assay
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Apoptosis Analysis
Voir tous les produits spécifiques à Isoform TNF Receptor
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Activité biologique
Description
IC50 & Target
[1]|
NF-κB |
NLRP3 |
IL-1β |
IL-6 |
In Vitro
Muscone significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in Bone marrow-derived macrophages (BMDMs). Muscone serves as a promising and effective drug for post-myocardial infarction (MI) treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 541-91-3
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Appearance Liquid (Density: 0.9221 g/cm3)
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Masse moléculaire 238.41
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Formule C16H30O
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Color Colorless to light yellow
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SMILES
O=C1CC(C)CCCCCCCCCCCC1
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Structure Classification
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Initial Source
musk
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
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Journal Impact Factor
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Most Recent
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Sci Rep
Muscone suppresses inflammation and senescence of nucleus pulposus via p53 signalling during intervertebral disc degeneration. [Abstract]2025 Aug 14;15(1):29794. PMID: 40813817
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
CCK-8 cell viability assay of different concentrations of Muscone (10, 25, 50, 100 μM) on NP cells.
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
qPCR analysis showing the relative mRNA level of ACAN, COL2 and CHSY1 expression under different concentrations of Muscone (10, 25, 50, 100 μM) treatment groups.
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
The protein levels of MMP1, MMP3, MMP13, ADAMTS4, ACAN, CHSY1 and GAPDH expression were assessed by Western Blot treated with Muscone (MUSE) (10, 25, 50 μM).
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
Representative mi-croscopy images of Transwell invasion assay of NP cells treated with Muscone.
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
Annexin V-FITC/PI Double-staining apoptosis assay showing the percentage of apoptotic percentage of NP cell under IL-1β and IL-1β + Muscone treatment.
Muscone purchased from MedChemExpress. Usage Cited in: Sci Rep. 2025 Aug 14;15(1):29794. [Abstract]
TUNEL assay was used to measure cell apoptosis of NP cells under IL-1β treated with Muscone.
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J Biochem Mol Toxicol
Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction. [Abstract]2023 Nov;37(11):e23458. PMID: 37455625 -
Cell Immunol
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR-γ pathway after ischemic stroke. [Abstract]2023 Apr:386:104704. PMID: 36921554
Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Apr:386:104704. [Abstract]
Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) obviously reduces the infarct volume in mice.
Muscone purchased from MedChemExpress. Usage Cited in: Cell Immunol. 2023 Apr:386:104704. [Abstract]
Muscone (8 mg/kg; i.p.; once a day for 7 consecutive days) significantly decreases the expression levels of pro-inflammatory proteins including TNF-α, IL-1β and IL-6 in mice distal middle cerebral artery occlusion (dMCAO) model.
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Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (419.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.49 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocole
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LPS-Induced Endotoxemia/Systemic Inflammation
Lipopolysaccharide (LPS)-induced endotoxemia is a widely used in vivo model of acute systemic inflammation in which LPS, a Gram-negative bacterial endotoxin, activates innate immune signaling primarily through TLR4, leading to rapid and transient induction of pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β in circulation and tissues. This cytokine surge is commonly used as a measurable readout of systemic inflammatory activation and immune dysregulation, and is typically assessed within hours after intraperitoneal LPS administration in mouse models of endotoxemia. The model captures key features of systemic inflammatory response syndrome, including cytokine release, immune cell activation, and downstream tissue responses, and has been used to evaluate anti-inflammatory interventions such as cytokine modulation, lipid mediators, and immune cell-targeting therapies.
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
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Pyroptosis Solutions
Pyroptosis is a lytic inflammatory cell-death pathway executed by gasdermin pores, most classically through inflammasome-mediated activation of caspase-1, cleavage of gasdermin D, membrane pore formation, LDH release, and secretion of IL-1β and IL-18. The canonical pathway is commonly modeled by priming cells with an inflammatory signal such as LPS to induce pro-IL-1β and inflammasome components, followed by an activation signal such as ATP or nigericin to activate NLRP3, ASC speck formation, caspase-1 cleavage, GSDMD cleavage, cytokine release, and pyroptotic membrane rupture. The non-canonical pathway is triggered when cytosolic LPS activates mouse caspase-11 or human caspase-4/5, leading to GSDMD cleavage and pyroptosis, and this can secondarily activate NLRP3-dependent IL-1β release. Pyroptosis is linked to inflammatory injury, infection, cancer, liver disease, ocular disease, placental inflammation, and other disease phenotypes, but unresolved questions include which gasdermin fam
Pureté et documentation
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Fiche technique (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1945 mL | 20.9723 mL | 41.9445 mL | 104.8614 mL |
| 5 mM | 0.8389 mL | 4.1945 mL | 8.3889 mL | 20.9723 mL | |
| 10 mM | 0.4194 mL | 2.0972 mL | 4.1945 mL | 10.4861 mL | |
| 15 mM | 0.2796 mL | 1.3982 mL | 2.7963 mL | 6.9908 mL | |
| 20 mM | 0.2097 mL | 1.0486 mL | 2.0972 mL | 5.2431 mL | |
| 25 mM | 0.1678 mL | 0.8389 mL | 1.6778 mL | 4.1945 mL | |
| 30 mM | 0.1398 mL | 0.6991 mL | 1.3982 mL | 3.4954 mL | |
| 40 mM | 0.1049 mL | 0.5243 mL | 1.0486 mL | 2.6215 mL | |
| 50 mM | 0.0839 mL | 0.4194 mL | 0.8389 mL | 2.0972 mL | |
| 60 mM | 0.0699 mL | 0.3495 mL | 0.6991 mL | 1.7477 mL | |
| 80 mM | 0.0524 mL | 0.2622 mL | 0.5243 mL | 1.3108 mL | |
| 100 mM | 0.0419 mL | 0.2097 mL | 0.4194 mL | 1.0486 mL |
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