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Cat. No.: HY-160528

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IBG3

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC₅₀ values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia.

For research use only. We do not sell to patients.

Purity: 98.53%
Formula: C₅₄H₅₇N₉O₅S₂
Molecular Weight:976.22

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IBG3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

BRD2

8.6 pM (DC₅₀)

BRD4

6.7 pM (DC₅₀)

All Epigenetic Reader Domain Isoforms :

In Vitro

IBG3 (6 h) potently degrades BRD4^Tandem in KBM7 cells, with a DC₅₀ value of 6.7 pM, which is more potent than IBG1 and dBET6^[1].
IBG3 (1 nM-10 μM; 30 min) promotes the formation of the BRD4-DCAF16 ternary complex in vitro, with an EC₅₀ of 32 nM, and exhibits stronger complex-stabilizing activity compared with IBG1^[1].
IBG3 (1 pM-100 μM; 5 h) potently degrades BRD2 (DC₅₀ = 8.6 pM) and BRD4 in HEK293 HiBiT knock-in cells, but shows no effect on BRD3, with higher efficiency than IBG1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Appearance Solid
Molecular Weight 976.22
Formula C₅₄H₅₇N₉O₅S₂
Color Off-white to light yellow
SMILES

O=C(NCC1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1)C5=CC=C(C6=CC=C(C7=N[C@@H](CC(OC(C)(C)C)=O)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Structure

CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1. [Abstract]

2026 Mar 20:S0969-2126(26)00056-0. PMID: 41864201

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (102.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0244 mL

5.1218 mL

10.2436 mL

5 mM

0.2049 mL

1.0244 mL

2.0487 mL

10 mM

0.1024 mL

0.5122 mL

1.0244 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration Concentration

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hsia O, et al. Targeted protein degradation via intramolecular bivalent glues. Nature. 2024;627(8002):204-211. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0244 mL	5.1218 mL	10.2436 mL	25.6090 mL
	5 mM	0.2049 mL	1.0244 mL	2.0487 mL	5.1218 mL
	10 mM	0.1024 mL	0.5122 mL	1.0244 mL	2.5609 mL
	15 mM	0.0683 mL	0.3415 mL	0.6829 mL	1.7073 mL
	20 mM	0.0512 mL	0.2561 mL	0.5122 mL	1.2804 mL
	25 mM	0.0410 mL	0.2049 mL	0.4097 mL	1.0244 mL
	30 mM	0.0341 mL	0.1707 mL	0.3415 mL	0.8536 mL
	40 mM	0.0256 mL	0.1280 mL	0.2561 mL	0.6402 mL
	50 mM	0.0205 mL	0.1024 mL	0.2049 mL	0.5122 mL
	60 mM	0.0171 mL	0.0854 mL	0.1707 mL	0.4268 mL
	80 mM	0.0128 mL	0.0640 mL	0.1280 mL	0.3201 mL
	100 mM	0.0102 mL	0.0512 mL	0.1024 mL	0.2561 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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IBG3

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Molecular Glue Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IBG3

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

IBG3

Epigenetics Compound Library

Histone Modification Research Compound Library

Anti-Cancer Compound Library

Reprogramming Compound Library

Anti-Blood Cancer Compound Library

Molecular Glue Compound Library

Anti-Hematopathy Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) IBG3

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

IBG3 Related Classifications

HY-160528 Related Classifications