VU0477886
VU0477886 is a metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator with potent activating activity on mGlu4 (EC50 = 95nM, 89% Glu Max), good pharmacokinetic characteristics (brain: plasma Kp = 1.3), and significant therapeutic efficacy in Parkinson's disease models.
For research use only. We do not sell to patients.
- CAS No.: 1926222-30-1
- Formula: C20H13ClN4O3
- Molecular Weight:392.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.095 nM
Compound: 17a; VU0477886
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Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assay
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[PMID: 27131990] |
Chemical Information
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CAS No. 1926222-30-1
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Molecular Weight 392.80
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Formula C20H13ClN4O3
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SMILES
O=C(C1=NC=CC=C1N)NC2=CC=C(N3C(C4=C(C3=O)C=CC=C4)=O)C(Cl)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU0477886 Related Classifications
HY-115796 Related Classifications
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