PD-1/PD-L1-IN-54 

PD-1/PD-L1-IN-54 (Compound 6) is a moderately affinic PD-1/PD-L1 inhibitor (K_D: PD-1, 55.8 μM; PD-L1, 46.4 μM; IC₅₀: 88.6 μM). PD-1/PD-L1-IN-54 inhibits PD-1/PD-L1 interactions and shows anticancer activity by activating CD8⁺ T cells, upregulating PD-1 expression, and increasing secretion of IFN-γ and IL-2. PD-1/PD-L1-IN-54 inhibits cancer cell proliferation and promotes apoptosis. PD-1/PD-L1-IN-54 also regulates T cell immunity through the PI3K/Akt pathway correlated with PD-1/PD-L1^[1].

PD-1/PD-L1-IN-54 (15-60 μM, 48 h) facilitates the proliferation of CD8⁺ T cells and inhibits the expansion of tumor cells (LLC and MC38) ^[1].
PD-1/PD-L1-IN-54 (15-60 μM, 48 h) promotes secretion of immune cytokines (IFN-γ and IL-2) in CD8⁺ T cells, and promotes apoptosis of tumor cells (LLC and MC38) in the co-culture system^[1].
PD-1/PD-L1-IN-54 (15-60 μM, 48 h) increases PD-1 expression on CD8⁺ T cells cocultured with LLC or MC38 cells^[1].
PD-1/PD-L1-IN-54 (15-60 μM, 48 h) activates the PI3K/Akt and NF-κB pathway, the downstream pathways of PD-1/PD-L1 interactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

368.77

C₁₇H₁₇ClO₇

1393644-68-2

COC1=CC(O)=C(C(OC)=O)C(OC2=C(C)C=C(O)C=C2OC)=C1Cl

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kuang QX, et al. New benzophenone analogs from Nigrospora sphaerica and their inhibitory activity against PD-1/PD-L1 interactions. Bioorganic chemistry, 2024, 153, 107899.  [Content Brief]