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Cat. No.: HY-10683R

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PK_i-402 (Standard)

Name: PKi-402 (Standard)
Brand: MedChemExpress
SKU: HY-10683R
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

PK_i-402 (Standard) is the analytical standard of PK_i-402 (HY-10683). This product is intended for research and analytical applications. PK_i-402 is a selective, reversible, ATP-competitive inhibitor of PI3K, including PI3K-α mutants, and mTOR (IC₅₀=2, 3, 7,14 and 16 nM for PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ).

For research use only. We do not sell to patients.

CAS No.: 1173204-81-3
Formula: C₂₉H₃₄N₁₀O₃
Molecular Weight:570.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PK_i-402 (Standard) Chemical Structure

CAS No.: 1173204-81-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

IC50: 2 nM (PI3Kα), 3 nM (mTOR), 7 nM (PI3Kβ),14 nM (PI3Kδ), 16 nM (PI3Kγ)^[1]

All PI3K Isoforms :

All mTOR Isoforms :

Chemical Information

CAS No. 1173204-81-3
Molecular Weight 570.65
Formula C₂₉H₃₄N₁₀O₃
SMILES

CCN1N=NC2=C1N=C(N=C2N3CCOCC3)C4=CC=C(C=C4)NC(NC5=CC=C(C=C5)C(N6CCN(CC6)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mallon R et al. Antitumor efficacy profile of PKI-402, a dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor. Mol Cancer Ther. 2010 Apr;9(4):976-84. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Protocols
Purity & Documentation
References

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PKi-402 (Standard)

All PI3K Isoforms

All mTOR Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Protocols

Purity & Documentation

References

Calculators

Help & FAQs

PKi-402 (Standard) Related Classifications

HY-10683R Related Classifications

Bioz

Keywords

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PK_i-402 (Standard)

IC₅₀ & Target

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