PLSRTLSVAAK
PLSRTLSVAAK is a peptide substrate used for the detection of PKC phosphorylation activity, and can be applied to in vitro kinase activity assays of PKCδ.
For research use only. We do not sell to patients.
- CAS No.: 105802-83-3
- Formula: C50H91N15O15
- Molecular Weight:1142.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PKCδ |
PLSRTLSVAAK (0.4 μg/μl; 30 min at 30°C) incubation of membrane-bound PKC preparations from BALB/c mouse hippocampal slices results in measurable substrate phosphorylation, while identical incubation with preparations from C57BL/6N mouse hippocampal slices shows no detectable phosphorylation[1].
PLSRTLSVAAK kinase-active c-Abl activates GST-PKCδ, which then increases phosphorylation of the PLSRTLSVAAK peptide substrate by a mean fold-increase of ~5 relative to PKCδ alone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 105802-83-3
-
Molecular Weight 1142.35
-
Formula C50H91N15O15
-
Sequence
Pro-Leu-Ser-Arg-Thr-Leu-Ser-Val-Ala-Ala-Lys
-
Sequence Shortening
PLSRTLSVAAK
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Blank T, Nijholt I, Grammatopoulos D K, et al. Corticotropin-releasing factor receptors couple to multiple G-proteins to activate diverse intracellular signaling pathways in mouse hippocampus: role in neuronal excitability and associative learning[J]. Journal of Neuroscience, 2003, 23(2): 700-707. [Content Brief]
[2]. Yuan Z M, Utsugisawa T, Ishiko T, et al. Activation of protein kinase C δ by the c-Abl tyrosine kinase in response to ionizing radiation[J]. Oncogene, 1998, 16 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLSRTLSVAAK Related Classifications
HY-P11877 Related Classifications
Powered by Bioz