PROTAC BRD4 Degrader-26

PROTAC BRD4 Degrader-26 (PROTAC-2) (0.01-10 µM; 6-24 h) induces concentration-dependent degradation of BRD4 in MCF-7 cells, reducing BRD4 levels by more than 80% after treatment with 1 µM for 24 h, and a hook effect is observed at 10 µM^[1].
PROTAC BRD4 Degrader-26 (1 µM; 18 h) mediates the degradation of BRD4 in MCF-7 cells via a pathway dependent on the ubiquitin-proteasome system and requiring the activity of CRL-type E3 ligases^[1].
PROTAC BRD4 Degrader-26 (0-120 min 365 nm UV exposure) undergoes rapid cleavage upon irradiation with 365 nm UV light, and complete degradation is observable within 30 min^[1].
PROTAC BRD4 Degrader-26 (1 µM; 30 min 365 nm UV exposure, 24 h post-UV incubation) undergoes inactivation in MCF-7 cells upon immediate 365 nm UV irradiation for 30 minutes, which significantly impairs its ability to degrade BRD4^[1].
PROTAC BRD4 Degrader-26 (1 µM; 6 h pre-incubation, 30 min 365 nm UV exposure, 24 h post-UV incubation) undergoes inactivation in MCF-7 cells upon 30 min of 365 nm UV irradiation at 6 h post-treatment, thereby reducing its BRD4 degradation efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.