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Cat. No.: HY-181553

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PROTAC BRD4 Degrader-44

PROTAC BRD4 Degrader-44 is a BRD4 PROTAC degrader with a DC₅₀ of 16 nM. PROTAC BRD4 Degrader-44 is applicable to studies on membrane-permeable PROTACs.
(Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-103596); Black: linker).

For research use only. We do not sell to patients.

Formula: C₃₉H₃₈ClN₇O₈S
Molecular Weight:800.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

PROTAC BRD4 Degrader-44 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC BRD4 Degrader-44 is a BRD4 PROTAC degrader with a DC₅₀ of 16 nM. PROTAC BRD4 Degrader-44 is applicable to studies on membrane-permeable PROTACs^[1]. (Pink: BRD4 ligand (HY-78695); Blue: Cereblon ligand (HY-103596); Black: linker).

IC₅₀ & Target

BRD4

All PROTACs Isoforms :

All Epigenetic Reader Domain Isoforms :

In Vitro

PROTAC BRD4 Degrader-44 (Compound 2a) (1 μM; 0.5-6 h) exhibits high stability in medium containing 10% FBS and moderate stability in mouse liver microsomes without NADPH; only 1.70% of the compound remains after incubation for 30 min in the presence of NADPH^[1].
PROTAC BRD4 Degrader-44 (10 μM; 0.5-6 h) accumulates in MCF-7 cells, with intracellular concentrations higher than those of dBET1 at all tested time points, and reaches levels comparable to its diastereomer after 6 h of incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MCF-7 cells
Concentration:

10, 30, 100, 300, 1000, 3000, 10000 nM
Incubation Time:

4 h
Result:

Exhibited a half-maximal degradation concentration (DC₅₀) of 16 nM, representing approximately a 5-fold enhancement in BRD4 degradation activity compared to dBET1.
Showed a hook effect.

Chemical Information

Molecular Weight 800.28
Formula C₃₉H₃₈ClN₇O₈S
SMILES

CC1=C(SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N24)C)CC(O[C@@H](CCC(NCCOC5=CC=CC(C6=O)=C5C(N6C7C(NC(CC7)=O)=O)=O)=O)C)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Abdelwahid MAS, et al. Diastereomeric Branched-Ester dBET1 Analogs Exhibit Conformation-Dependent Differences in Passive Membrane Permeability. J Med Chem. 2026;69(3):2900-2915. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC BRD4 Degrader-44

All PROTACs Isoforms

All Epigenetic Reader Domain Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC BRD4 Degrader-44 Related Classifications

HY-181553 Related Classifications