1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. SB228357

SB228357 

Cat. No.: HY-103154
Handling Instructions

SB228357 is a selective, potent oral active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.

For research use only. We do not sell to patients.

SB228357 Chemical Structure

SB228357 Chemical Structure

CAS No. : 181629-93-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 427 In-stock
Estimated Time of Arrival: December 31
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 770 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SB228357 is a selective, potent oral active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects[1][2].

IC50 & Target[1]

5-HT2A Receptor

6.9 (pKi)

5-HT2C Receptor

9 (pKi)

5-HT2B Receptor

8 (pKi)

In Vivo

SB228357 (0-10 mg/kg; oral administration; for 90 minutes; male Sprague Dawley rats) treatment significantly reverses Haloperidol-induced catalepsy[2].

Animal Model: Male Sprague Dawley rats (200-250 g) injected with Haloperidol[2]
Dosage: 0 mg/kg, 0.32 mg/kg, 1 mg/kg, 3.2 mg/kg, 10 mg/kg
Administration: Oral administration; for 90 minutes
Result: Significantly reversed Haloperidol-induced catalepsy.
Molecular Weight

431.38

Formula

C₂₂H₁₇F₄N₃O₂

CAS No.

181629-93-6

SMILES

O=C(N1CCC2=C1C=C(C(F)(F)F)C(OC)=C2)NC3=CC(C4=CC=CN=C4)=CC(F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SB228357
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HY-103154
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