Pseudobaptigenin
Based on 2 publication(s) in Google Scholar
Pseudobaptigenin is a natural isoflavone polyphenolic compound. Pseudobaptigenin is generated through the CYP76F319-catalyzed conversion of Calycosin (HY-N0519) and can serve as a precursor for phytoalexin synthesis. Pseudobaptigenin is predicted to have potential as an inhibitor of ER, PR, and HER2. Pseudobaptigenin can be used in research on breast cancer and metabolism-related diseases.
For research use only. We do not sell to patients.
- Purity : 98.41%
- CAS No.: 90-29-9
- Formula: C16H10O5
- Molecular Weight:282.25
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pseudobaptigenin
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BV-2 | IC50 |
>100 μM
Compound: 20
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Anti-neuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Anti-neuroinflammatory activity against mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 25466192] |
| C2C12 | IC50 |
12.08 μg/mL
Compound: 7
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Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability by MTT assay
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[PMID: 33412152] |
| HEK293 | EC50 |
22.34 μM
Compound: 7
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Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
Agonist activity at human PPARdelta expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
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[PMID: 23265844] |
| HEK293 | EC50 |
26.94 μM
Compound: 7
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Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
Agonist activity at human PPARgamma expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
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[PMID: 23265844] |
| HEK293 | EC50 |
8.9 μM
Compound: 7
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Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
Agonist activity at human PPARalpha expressed in HEK293 cells cotransfected with PPREx4-TK-luc assessed as activation of luciferase activity measured after 48 hrs by transactivation assay
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[PMID: 23265844] |
| MCF7 | IC50 |
>100 μM
Compound: 30a
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against human MCF7 cells after 72 hrs by MTS/PMS assay
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[PMID: 19932969] |
| SK-BR-3 | IC50 |
>100 μM
Compound: 30a
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Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS/PMS assay
Antiproliferative activity against human SKBR3 cells after 72 hrs by MTS/PMS assay
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[PMID: 19932969] |
In Vitro
Pseudobaptigenin (molecular docking) can bind to estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2); its molecular docking binding free energies ΔG are -6.49 kCal/mole, -6.87 kCal/mole, and -5.84 kCal/mole, respectively, and the corresponding MM‑GBSA binding free energies are -44.10 kCal/mol, -42.37 0.39 kCal/mol, and -32.71 kCal/mol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90-29-9
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Appearance Solid
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Molecular Weight 282.25
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Formula C16H10O5
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Color Light yellow to light brown
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SMILES
O=C1C2=CC=C(C=C2OC=C1C3=CC4=C(OCO4)C=C3)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
Solvent & Solubility
In Vitro:
DMSO : 35.71 mg/mL (126.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5430 mL | 17.7148 mL | 35.4296 mL | 88.5740 mL |
| 5 mM | 0.7086 mL | 3.5430 mL | 7.0859 mL | 17.7148 mL | |
| 10 mM | 0.3543 mL | 1.7715 mL | 3.5430 mL | 8.8574 mL | |
| 15 mM | 0.2362 mL | 1.1810 mL | 2.3620 mL | 5.9049 mL | |
| 20 mM | 0.1771 mL | 0.8857 mL | 1.7715 mL | 4.4287 mL | |
| 25 mM | 0.1417 mL | 0.7086 mL | 1.4172 mL | 3.5430 mL | |
| 30 mM | 0.1181 mL | 0.5905 mL | 1.1810 mL | 2.9525 mL | |
| 40 mM | 0.0886 mL | 0.4429 mL | 0.8857 mL | 2.2143 mL | |
| 50 mM | 0.0709 mL | 0.3543 mL | 0.7086 mL | 1.7715 mL | |
| 60 mM | 0.0590 mL | 0.2952 mL | 0.5905 mL | 1.4762 mL | |
| 80 mM | 0.0443 mL | 0.2214 mL | 0.4429 mL | 1.1072 mL | |
| 100 mM | 0.0354 mL | 0.1771 mL | 0.3543 mL | 0.8857 mL |
Pseudobaptigenin Related Classifications
HY-N10616 Related Classifications
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