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Cat. No.: HY-110093

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UNC0638 hydrate

12 Cited Publications

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Based on 12 publication(s) in Google Scholar

UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC₅₀ of 15 nM and 19 nM, respectively. UNC0638 hydrate inhibits TNBC cell invasion and migration in vitro. UNC0638 hydrate is also an inhibitor of EHMT1/2 and induces fetal hemoglobin (HbF) expression in human erythroid progenitor cell culture. In addition, UNC0638 hydrate has anti-FMDV (foot-and-mouth disease virus) and anti-VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets.

For research use only. We do not sell to patients.

CAS No.: 1255517-77-1
Formula: C₃₀H₄₉N₅O₃
Molecular Weight:527.74

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

UNC0638 hydrate Chemical Structure

CAS No.: 1255517-77-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (12)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: <15 nM (G9a), 19±1 nM (GLP)^[1]

All Histone Methyltransferase Isoforms :

Chemical Information

CAS No. 1255517-77-1
Molecular Weight 527.74
Formula C₃₀H₄₉N₅O₃
SMILES

CC(N1CCC(NC2=C3C=C(OC)C(OCCCN4CCCC4)=CC3=NC(C5CCCCC5)=N2)CC1)C.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (12)

All WBCell Proliferation/Viability AssayCell Migration/Invasion AssayRT-PCR

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Journal Impact Factor

Cancer Res

TNG917 is a Potent and Selective Inhibitor of Histone Lysine Methyltransferases EHMT1/2 that Enhances Anti-Tumor Immunity and Immunotherapy Efficacy. [Abstract]

2026 Jun 10. PMID: 42268285
Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175
Cell Death Dis

Targeting EHMT2 reverses EGFR-TKI resistance in NSCLC by epigenetically regulating the PTEN/AKT signaling pathway. [Abstract]

2018 Jan 26;9(2):129. PMID: 29374157

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

The effects of treatment with UNC0638 (10 μM) on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

The EHMT2 inhibitor UNC0638 (5-10 μM; 48 h) effectively inhibited cell growth in both PC9/ER and HCC827/ER cells.

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

UNC0638 (100 nM; 48 h) suppressed cell migration in PC9 and PC9/ER cells.

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

UNC0638 (100 nM; 48 h) pretreatment enhanced the sensitivity of PC9/ER cells to Erlotinib compared to non-pretreated cells.

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Treatment with UNC0638 (10 μM) resulted in the downregulation of Bcl-2 and VEGF in EGFR-TKI-resistant NSCLC cell lines.
Acta Pharmacol Sin

DNMT inhibition epigenetically restores the cGAS-STING pathway and activates RIG-I/MDA5-MAVS to enhance antitumor immunity. [Abstract]

2025 Aug 19. PMID: 40830678
Acta Pharmacol Sin

P300/CBP inhibition sensitizes mantle cell lymphoma to PI3Kδ inhibitor idelalisib. [Abstract]

2022 Feb;43(2):457-469. PMID: 33850273
Proc Natl Acad Sci U S A

MGMT-activated DUB3 stabilizes MCL1 and drives chemoresistance in ovarian cancer. [Abstract]

2019 Feb 19;116(8):2961-2966. PMID: 30718431
Cell Chem Biol

Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells. [Abstract]

2022 Jul 21;29(7):1153-1161.e5. PMID: 35728598
Cell Biosci

Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification. [Abstract]

2023 Jan 12;13(1):7. PMID: 36631841
Mol Med Rep

UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer. [Abstract]

2018 Feb;17(2):2239-2244. PMID: 29207160

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Feb;17(2):2239-2244. [Abstract]

UNC0638 (0.5 and 1 µM; 24 h) suppressed triple negative breast cancer cell migration and invasion by regulating EMT-associated proteins. Western blots of EMT-associated proteins were performed.
J Neurosci

Histone Methyltransferase G9a in Primary Sensory Neurons Promotes Inflammatory Pain and Transcription of Trpa1 and Trpv1 via Bivalent Histone Modifications. [Abstract]

2025 Jan 17:e1790242024. PMID: 39824634
Mol Carcinog

A novel high-risk model identified by epithelial-mesenchymal transition predicts prognosis and radioresistance in rectal cancer. [Abstract]

2024 Nov;63(11):2119-2132. PMID: 39056517
bioRxiv

2023 Nov 17.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vedadi M, et al. A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. [Content Brief]

[2]. Fu L, et al. Effects of the Histone Methyltransferase Inhibitor UNC0638 on Histone H3K9 Dimethylation of Cultured Ovine Somatic Cells and Development of Resulting Early Cloned Embryos. Reprod Domest Anim. 2014 Apr;49(2):e21-5. [Content Brief]

[3]. Singh N, et al. Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. J Interferon Cytokine Res. 2016 Jan;36(1):37-47. [Content Brief]

[4]. Liu X R, et al. UNC0638, a G9a inhibitor, suppresses epithelial‑mesenchymal transition‑mediated cellular migration and invasion in triple negative breast cancer[J]. Molecular medicine reports, 2018, 17(2): 2239-2244. [Content Brief]

[5]. Nualkaew T, et al. UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells[J]. Annals of hematology, 2020, 99: 2027-2036. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

UNC0638 hydrate

12 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (12)
Purity & Documentation
References

1/16
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Customer Validation
The effects of treatment with UNC0638 (10 μM) on cleaved PARP (Clv-PARP) expression in both PC9/ER and HCC827/ER cells. β-actin is used as a loading control.
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Customer Validation
The EHMT2 inhibitor UNC0638 (5-10 μM; 48 h) effectively inhibited cell growth in both PC9/ER and HCC827/ER cells.
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Customer Validation
UNC0638 (100 nM; 48 h) suppressed cell migration in PC9 and PC9/ER cells.
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Customer Validation
UNC0638 (100 nM; 48 h) pretreatment enhanced the sensitivity of PC9/ER cells to Erlotinib compared to non-pretreated cells.
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 26;9(2):129. [Abstract]

Customer Validation
Treatment with UNC0638 (10 μM) resulted in the downregulation of Bcl-2 and VEGF in EGFR-TKI-resistant NSCLC cell lines.
1/16

UNC0638 hydrate purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2018 Feb;17(2):2239-2244. [Abstract]

Customer Validation
UNC0638 (0.5 and 1 µM; 24 h) suppressed triple negative breast cancer cell migration and invasion by regulating EMT-associated proteins. Western blots of EMT-associated proteins were performed.

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UNC0638 hydrate

Publications Citing Use of MedChemExpress (MCE) UNC0638 hydrate

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Publications (12)

Purity & Documentation

References

Calculators

Help & FAQs

UNC0638 hydrate Related Classifications

HY-110093 Related Classifications