Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
91 Results for "
SREBPs
" in MedChemExpress (MCE) Product Catalog:
Products (91)
91 Results for "SREBPs" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-N4253
CAS No.: 173792-61-5
1
1 Cited Publications
Cat. No.: HY-W015924
CAS No.: 594-61-6
Target:
Cat. No.: HY-N0466
CAS No.: 58543-16-1
Cat. No.: HY-170316
Ibetazol is a Importin β1 (KPNB1) inhibitor and nucleocytoplasmic transport disruptor. Ibetazol binds covalently to Cys585 of Importin β1, blocks both Importin β1-mediated direct transport and Importin α-dependent nuclear import processes, without affecting transport mediated by other nucleocytoplasmic transport proteins. Ibetazol induces cytoplasmic accumulation of Importin α1, and inhibits nuclear import of substrates carrying nuclear localization signals (NLS), including the NLS-cMyc reporter gene, RelA/p65 and SREBP1. Ibetazol triggers spindle malformation and chromosome misalignment by disrupting the mitotic function of Importin β1. Ibetazol inhibits the proliferation of cells expressing wild-type Importin β1. Ibetazol has a high activity-cytotoxicity window, lacks intrinsic fluorescence, and acts rapidly on nucleocytoplasmic transport processes. Ibetazol serves as a tool compound for investigating nuclear import processes specifically mediated by Importin β1 .
Cat. No.: HY-N1967
CAS No.: 76474-56-1
Category:
Zingiber officinale Roscoe Zingiberaceae Extract Metabolic Disease Phenols Polyphenols Plants Disease Research Fields
Target:
Cat. No.: HY-Y0319G
CAS No.: 16674-78-5
Cat. No.: HY-43515
Target:
Research Areas:
ESI1 is a small molecule epigenetic silencing inhibitor. ESI1 can trigger the formation of nuclear condensates of key lipid metabolism regulators SREBP1/2, concentrating transcriptional co-activators to drive lipid/cholesterol biosynthesis. ESI1 can promote myelin regeneration in demyelinated animal models and facilitate de novo myelination on regenerating CNS axons, reversing age-related declines in cognitive abilities .
Cat. No.: HY-156259
CAS No.: 2639372-47-5
Target:
Research Areas:
PF-07202954 is an orally active, highly selective DGAT2 inhibitor with an IC50 of 10 nM against human DGAT2 and an IC50 of 17 nM against rat DGAT2. PF-07202954 reduces triglyceride synthesis, decreases hepatic triglyceride content and plasma triglyceride levels, inhibits de novo lipogenesis, and suppresses the hepatic SREBP signaling pathway as well as the expression of SREBP target genes. PF-07202954 is applicable to research related to non-alcoholic steatohepatitis .
Cat. No.: HY-139576B
Purity: ≥97.0%
Synonyms: DUR-928 trimethylamine
Target:
Cat. No.: HY-W012865
CAS No.: 80-69-3
Research Areas:
Tartronic acid, a dicarboxylic acid derive, is an inhibitor of the transformation of carbohydrates into fat under fat-deficient diet conditions. Tartronic acid promotes 3T3-L1 adipocyte differentiation by increasing the protein expression of FABP-4, PPARγ and SREBP-1. Tartronic acid promotes de novo lipogenesis and inhibits CPT-1β by upregulating acetyl-CoA and malonyl-CoA. Tartronic acid promotes weight gain and induces adipocyte hypertrophy in epididymal white adipose tissue and lipid accumulation in the livers of high-fat diet induced obese mice. Tartronic acid can be used for lipid metabolic disease research .
Cat. No.: HY-N14035
CAS No.: 90045-23-1
Cat. No.: HY-N12124
CAS No.: 1011244-19-1
Synonyms: Monascinol
Cat. No.: HY-N0082
CAS No.: 73069-28-0
Synonyms: Praeruptorin D
Category:
Umbelliferae Extract Salvia hypargeia Fisch. & C.A.Mey. Metabolic Disease Coumarins Phenylpropanoids Plants Disease Research Fields
Target:
Cat. No.: HY-W006398S
CAS No.: 39230-37-0
Synonyms: Anhydrous sodium acetate-d3
Cat. No.: HY-W587772
CAS No.: 1684398-38-6
Synonyms: MEHHTP
Target:
Research Areas:
Mono (2-ethyl-5-hydroxyhexyl) terephthalate (MEHHTP), a hydroxyl metabolite of the phthalate alternative Di-2-ethylhexyl terephthalate (DEHTP), is a liver X receptor α (LXRα) agonist with a binding energy of -7.41 kcal/mol. Mono (2-ethyl-5-hydroxyhexyl) terephthalate upregulates LXRα downstream targets such as SREBP-1c and FASN and increases lipogenic enzyme activity in hepatocytes, and elevating triglyceride (TG) levels. Mono (2-ethyl-5-hydroxyhexyl) terephthalate is promising for research of nonalcoholic fatty liver disease (NAFLD) .
Cat. No.: HY-139576
CAS No.: 884905-07-1
Synonyms: DUR-928
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
