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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
366 Results for "
TNF expression
" in MedChemExpress (MCE) Product Catalog:
Products (366)
366 Results for "TNF expression" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-N2464
CAS No.: 34612-38-9
Synonyms: Amylotetraose; Fujioligo 450; α-1,4-Tetraglucose
3
3 Cited Publications
Cat. No.: HY-N0316
CAS No.: 55481-88-4
3
3 Cited Publications
Cat. No.: HY-163731
CAS No.: 3077196-25-6
Research Areas:
EGR-1-IN-1 is a EGR-1 inhibitor with an IC50 of 1.86 μM. EGR-1-IN-1 binds to the zinc finger DNA-binding domain of EGR-1 and promotes the dissociation of the EGR-1-DNA complex. EGR-1-IN-1 reduces the mRNA expression levels of EGR-1-regulated inflammatory genes induced by TNFα. EGR-1-IN-1 alleviates atopic dermatitis-like lesions in the ear skin of mice. EGR-1-IN-1 serves as a lead compound for the development of targeted compounds for inflammatory skin diseases. EGR-1-IN-1 can be used in studies related to atopic dermatitis .
3
3 Cited Publications
Synonyms: Halite, meets analytical specification of Ph. Eur. BP USP
3
3
3 Cited Publications
Cat. No.: HY-108910A
CAS No.: 9004-07-3
Synonyms: EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)
Target:
Research Areas:
Chymotrypsin (EC 3.4.21.1; Chymotrypsin A) (MS grade) is an orally effective inhibitor targeting molecules such as TLR4, NF-κB, MMP-1, TNF-α, IL-1β, and IL-6. Chymotrypsin (MS grade) downregulates the TLR4/NF-κB signaling pathway, inhibits the release of inflammatory factors, reduces cell infiltration and tissue damage, and also reduces the expression of tumor cell adhesion molecules (such as CD44 and CD54). It can also be specifically detected by fluorescent probes (such as NBD-3). Chymotrypsin (MS grade) has anti-inflammatory, hepatoprotective, joint damage-reducing, liver protection against lipotoxicity, and anti-tumor metastasis functions, and can be used in the research of diseases such as rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Chymotrypsin (MS grade) can be used in studies of inflammation, edema, and expectoration .
2
2 Cited Publications
2
2 Cited Publications
Cat. No.: HY-121309
CAS No.: 24385-10-2
Synonyms: Adriamycin aglycone; Adriamycinone
2
2 Cited Publications
Cat. No.: HY-N1921
CAS No.: 32685-93-1
2
Category:
Alkaloids Chelidonium majus Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Papaveraceae
Target:
2
2
2 Cited Publications
Research Areas:
HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 reduces the expression of TNF, IL-6, and IL-1β. HS-276 can be used for rheumatoid arthritis (RA) research .
2
2 Cited Publications
Cat. No.: HY-W040045
CAS No.: 18466-51-8
Synonyms: Pelargonidin-3-O-glucoside chloride
2
2
Pexmetinib (ARRY-614) is an orally active dual Tie-2 and p38 MAPK inhibitor. Pexmetinib binds to Tie-2 and p38 MAPK in a "DFG-out" conformation, attenuates the phosphorylation of p38, inhibits STAT3 activation, reduces the promoter-binding activity of NFATc1, and decreases the expression of MMPs. Pexmetinib inhibits leukemia cell proliferation, abrogates TNF-α-mediated myelosuppression of healthy hematopoietic stem cells, stimulates hematopoiesis in primary myelodysplastic syndrome (MDS) samples, inhibits RANKL-induced osteoclast formation and bone resorption, and suppresses migration, invasion and induced osteolysis of breast cancer cells. Pexmetinib can be used in research related to myelodysplastic syndrome, acute myeloid leukemia and breast cancer-induced osteolysis .
2
Category:
Flavonoids Flavones Cruciferae Isatis tinctoria L. Phenols Polyphenols Plants Disease Research Fields Cancer
Target:
2
2 Cited Publications
Cat. No.: HY-N2473
CAS No.: 94367-42-7
2
1
Research Areas:
Lubiprostone (SPI-0211) increases intestinal fluid secretion through generation of CIC-2/CFTR and activation of cAMP signaling pathway. Lubiprostone inhibits myeloperoxidase (MPO) activity, downregulates Indomethacin (HY-14397)-induced iNOS and TNFα expression. Lubiprostone can be used for chronic constipation research .
1
Category:
Cardiovascular Disease Alkaloids Phenols Polyphenols Plants Lauraceae Disease Research Fields Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.
Target:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
