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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
642 Results for "
4a
" in MedChemExpress (MCE) Product Catalog:
Products (642)
642 Results for "4a" in MCE Product Catalog:
2
2
2 Cited Publications
Cat. No.: HY-P73810
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP2; Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase); Prev. CLG4a; Collagenase Type IV-A; Prev. CLG4; Neutrophil Gelatinase; TBE-1; 72 KDa Gelatinase; MMP-2; Gelatinase A; 72 KDa Type IV Collagenase; MMP-II; Matrix M
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P80180
Synonyms: H4/A, H4FA, HIST1H4a, H4C2, H4/I, H4FI, HIST1H4B, H4C3, H4/G, H4FG, HIST1H4C, H4C4, H4/B, H4FB, HIST1H4D, H4C5, H4/J, H4FJ, HIST1H4E, H4C6, H4/C, H4FC, HIST1H4F, H4C8, H4/H, H4FH, HIST1H4H, H4C9, H4/M, H4FM, HIST1H4I, H4C11, H4/E, H4FE, HIST1H4J, H4C12, H4/D, H4FD, HIST1H4K, H4C13, H4/K, H4FK, HIST1H4L, H4C14, H4/N, H4F2, H4FN, HIST2H4, HIST2H4a, H4C15, H4/O, H4FO, HIST2H4B, H4C16, H4-16, HIST4H4, H4C1, Histone H4, H4K5ac
2
2 Cited Publications
Cat. No.: HY-P80182
Synonyms: H4/A, H4FA, HIST1H4a, H4C2, H4/I, H4FI, HIST1H4B, H4C3, H4/G, H4FG, HIST1H4C, H4C4, H4/B, H4FB, HIST1H4D, H4C5, H4/J, H4FJ, HIST1H4E, H4C6, H4/C, H4FC, HIST1H4F, H4C8, H4/H, H4FH, HIST1H4H, H4C9, H4/M, H4FM, HIST1H4I, H4C11, H4/E, H4FE, HIST1H4J, H4C12, H4/D, H4FD, HIST1H4K, H4C13, H4/K, H4FK, HIST1H4L, H4C14, H4/N, H4F2, H4FN, HIST2H4, HIST2H4a, H4C15, H4/O, H4FO, HIST2H4B, H4C16, H4-16, HIST4H4, H4C1, Histone H4, H4K5ac
1
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity .
1
1
1 Cited Publications
Research Areas:
eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM .
1
1 Cited Publications
Target:
1
1 Cited Publications
Target:
Research Areas:
4A7C-301 is a blood-brain barrier-permeable Nurr1 agonist, with IC50 values of 48.22 nM and 107.71 nM for binding to Nurr1-LBD in the [ 3H]-CQ competition assay and TR-FRET assay, respectively. The EC50 of 4A7C-301 for activating Nurr1 transcriptional activity is 6.53 μM, and its EC50 in N27-A dopaminergic cells is approximately 0.2 μM. 4A7C-301 binds directly to Nurr1-LBD, enhances the transcriptional function of Nurr1, and restores the reduction of Nurr1 protein induced by MPP + or αSyn. 4A7C-301 alleviates oxidative stress and mitochondrial dysfunction, protects midbrain dopaminergic neurons, inhibits microglial activation, and restores impaired autophagic flux. 4A7C-301 can be used in studies related to neuroprotection and Parkinson's disease .
1
1 Cited Publications
Cat. No.: HY-P76055
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SEMA4a; Semaphorin-4a; Prev. SEMAB; FLJ12287; CORD10; Sema B; SemB; RP35; Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4a; SEMB; Semaphorin 4a; Semaphorin-B
Species:
Human
Source:
HEK293
1
1 Cited Publications
Target:
Research Areas:
PF-06761281 (Compound 4a) is a potent, orally active, partial selective sodium-coupled citrate transporter (NaCT or SLC13A5) inhibitor with IC50 values of 0.51, 13.2 and 14.1 µM against HEKNaCT, HEKNaDC1 and HEKNaDC3, respectively .
1
1 Cited Publications
Target:
Research Areas:
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects .
1
1 Cited Publications
Target:
Research Areas:
CDC25B-IN-1 (compound 4a) is a potent inhibitor of cell division cycle 25B (CDC25B) phosphatase, with a Ki of 8.5 μM. CDC25B-IN-1 potently inhibits cell proliferation and colony formation, causes an increase of the G2/M phase .
1
1
1 Cited Publications
Cat. No.: HY-P86438
Synonyms: Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3; Cyclin-dependent kinase 4 inhibitor A; CDK4I; Multiple tumor suppressor 1; MTS-1; p16-INK4a; p16-INK4; p16INK4a; p16;
1
1 Cited Publications
Cat. No.: HY-P76138
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ALDH4a1; Mitochondrial Delta-1-Pyrroline 5-Carboxylate Dehydrogenase; Prev. ALDH4; Aldehyde Dehydrogenase 4 Family, Member A1; L-Glutamate Gamma-Semialdehyde Dehydrogenase; Epididymis Secretory Sperm Binding Protein; P5CDh; Multifunctional Fusion Protein
Species:
Human
Source:
Sf9 insect cells
1
1 Cited Publications
Cat. No.: HY-P81201
Synonyms: Arresten; Canstatin; COL4a1; HANAC; ICH; POREN1; Collagen Alpha 1(IV) Chain; Collagen IV Alpha 1 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; DKFZp686I14213; FLJ22259; collagen alpha-1(IV) chain preproprotein; collagen alpha-1(IV) chain preproprotein; Col4a1 protein; collagen of basement membrane, alpha-1 chain; collagen IV, alpha-1 polypeptide; collagen alpha-1(IV) chain; COL4a1 NC1 domain; CO4a1_HUMAN; Collagen Ⅳ; Collagen Type Ⅳ.
1
1
1 Cited Publications
Cat. No.: HY-P701139A
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: HNF4a; TCF-14; Prev. TCF14; Hepatocyte Nuclear Factor 4 4 Alpha Variant 4; Prev. MODY1; Hepatocyte Nuclear Factor 4 4 Alpha Variant 1; Prev. MODY; Hepatocyte Nuclear Factor 4 4 Alpha Variant 2; NR2A1; Truncated Hepatocyte Nuclear Factor 1 Alpha; HNF4; HNF
Species:
Human
Source:
HEK293
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
