546 Results for "

triphosphate

" in MedChemExpress (MCE) Product Catalog:
Products (546)

546 Results for "triphosphate" in MCE Product Catalog:

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1 Cited Publications
Cat. No.: HY-W008661
CAS No.: 93919-41-6
Synonyms: dGTP trisodium solution (100 mM); 2'-Deoxyguanosine-5'-triphosphate trisodium solution (100 mM)
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

Deoxyguanosine triphosphate (dGTP) trisodium solution (100 mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .
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1 Cited Publications
Cat. No.: HY-141567A
Purity:  ≥98.0%
Synonyms: Pseudo-UTP trisodium solution (100 mM)
Pseudouridine 5'-triphosphate (Pseudo-UTP) trisodium solution (100 mM) is a modified ribonucleoside triphosphate and uracil base-modified UTP derivative. Pseudouridine 5'-triphosphate trisodium solution (100 mM) enhances translational properties and stability of mRNA, reduces innate immune responses in mammalian cells, and inhibits signal-dependent transcription termination of vaccinia virus early gene transcription while supporting transcription elongation. Pseudouridine 5'-triphosphate trisodium solution (100 mM) can be used for the research of vaccinia virus infection .
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1 Cited Publications
Cat. No.: HY-147338A
Purity:  99.40%
Synonyms: 5-Methyl-CTP trisodium
5-Methylcytidine 5′-triphosphate trisodium (5-Methyl-CTP trisodium) is a modified cytidine triphosphate nucleotide. 5-Methylcytidine 5′-triphosphate trisodium serves as a modified nucleotide substrate for in vitro transcription, partially or completely replacing CTP. 5-Methylcytidine 5′-triphosphate trisodium enhances mRNA stability and translation efficiency, and reduces activation of the innate immune system. 5-Methylcytidine 5′-triphosphate trisodium is used in RNA synthesis-related research .
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1 Cited Publications
Cat. No.: HY-136650A
Purity:  99.56%
Synonyms: F-ara-ATP trisodium
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine (HY-B0069), is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis .
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1 Cited Publications
Cat. No.: HY-138616
CAS No.: 2564-35-4
Synonyms: 2'-Deoxyguanosine-5'-triphosphate
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP .
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1 Cited Publications
Cat. No.: HY-128036B
CAS No.: 72029-21-1
Purity:  99.93%
Synonyms: 2',3'-Dideoxyadenosine 5'-triphosphate trisodium
Target:  

DNA/RNA Synthesis HIV

Research Areas:  

Infection

ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection .
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1 Cited Publications
Cat. No.: HY-103642A
CAS No.: 141611-10-1
Purity:  99.8%
Synonyms: Inositol 1,4,5-trisphosphate trisodium; Ins(1,4,5)-P3 trisodium
Target:  

Calcium Channel

Research Areas:  

Metabolic Disease

D-myo-Inositol-1,4,5-triphosphate sodium salt is the trisodium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.
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1 Cited Publications
Cat. No.: HY-111815A
CAS No.: 2803886-33-9
Purity:  99.91%
Synonyms: ac4CTP sodium solution (100mM)
Target:  

Endogenous Metabolite

Research Areas:  

Others

N4-Acetylcytidine triphosphate sodium solution (100mM) is efficiently used as a substrate in T7 Polymerase-catalyzed in vitro transcription and it can be incorporated into multiple templates .
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1 Cited Publications
Cat. No.: HY-B2176S5
Synonyms: Adenosine 5'-triphosphate-15N5 dilithium
ATP- 15N5 (Adenosine 5'-triphosphate-ATP- 15N5) dilithium is the 15N5-labeled ATP (HY-B2176). ATP is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation. ATP can activate the NLRP3 inflammasome and induce IL-1β and chemokines secretion. ATP has anti-bacterial infection effects and can protect mice against bacterial infection in mice .
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1 Cited Publications
Cat. No.: HY-108666
CAS No.: 93839-89-5
Purity:  94.15%
Synonyms: Adenosine-5'-O-3-thiotriphosphate tetralithium salt; Adenosine 5'-[γ-thio]triphosphate tetralithium salt
ATPγS (tetralithium salt) is a P2Y11 receptor agonist, an antioxidant and a neuroprotective agent. ATPγS (tetralithium salt) can be used as a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. ATPγS (tetralithium salt) is active in ATP hydrolysis .
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1 Cited Publications
Cat. No.: HY-139165A
CAS No.: 1621884-18-1
Purity:  99.74%
Target:  

SARS-CoV

Research Areas:  

Infection

AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication .
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1 Cited Publications
Cat. No.: HY-106950A
CAS No.: 38099-82-0
Purity:  ≥98.0%
Synonyms: Diphosphofructose trisodium; Esafosfan trisodium; FDP trisodium
Fosfructose trisodium (Diphosphofructose trisodium, Esafosfan trisodium, FDP trisodium) is a cytoprotective natural sugar phosphate used in research on cardiovascular ischemia, sickle cell anemia, and asthma. Fosfructose trisodium acts by stimulating anaerobic glycolysis, which produces adenosine triphosphate under ischemic conditions .
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1 Cited Publications
Cat. No.: HY-W040055S
CAS No.: 1217632-04-6
Synonyms: D-(+)-Neopterin-13C5; D-erythro-Neopterin-13C5
Neopterin- 13C5 (D-(+)-Neopterin- 13C5; D-erythro-Neopterin- 13C5) is the deuterium labeled Neopterin (HY-W040055) . Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation .
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1 Cited Publications
Cat. No.: HY-W013159
CAS No.: 33430-61-4
Synonyms: 5′-dGMP disodium
2'-Deoxyguanosine 5'-monophosphate (5′-dGMP) disodium is a mononucleotide having guanine as the nucleobase. 2'-Deoxyguanosine 5'-monophosphate disodium is a reactant involved in analysis of self-assembling in solution and nucleation/growth of G-qudruplexes, nucleophilic trapping and reductive alkylation. 2'-Deoxyguanosine 5'-monophosphate disodium can be used as an oxidizable target. 2'-Deoxyguanosine 5'-monophosphate disodium is a nucleic acid guanosine triphosphate (GTP) derivative and is a nucleotide precursor used in DNA synthesis .
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1 Cited Publications
Cat. No.: HY-D1668
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .
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1 Cited Publications
Cat. No.: HY-D1056E
Synonyms: LPS, from Pseudomonas aeruginosa (10)
Lipopolysaccharides from P. aeruginosa (Pseudomonas aeruginosa) 10 are lipopolysaccharide endotoxins and TLR4 activators derived from Pseudomonas aeruginosa 10, and are classified as S-type LPS. Lipopolysaccharides from P. aeruginosa 10 exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. The lipopolysaccharides of P. aeruginosa 10 have a fatty acid composition distinct from common enterobacteria, an exceptionally high degree of phosphorylation (triphosphate residues have been detected), and a unique outer region of the core oligosaccharide. Additionally, their O-specific side chains are typically rich in novel aminosugars. Lipopolysaccharides from P. aeruginosa 10 demonstrate susceptibility to viruses, with the level of susceptibility determined by the content of high molecular weight polysaccharides in their composition. The absence of high molecular weight polysaccharides increases their sensitivity to bacteriophages .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.
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Cat. No.: HY-17026E
Synonyms: dFdCTP trisodium
Gemcitabine triphosphate (dFdCTP) trisodium is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate trisodium cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate trisodium shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate trisodium partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate trisodium disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate trisodium can be used for the research of pancreatic cancer and non-small cell lung cancer .
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Cat. No.: HY-107372
CAS No.: 63-39-8
Synonyms: UTP; Uridine 5'-triphosphate
Uridine triphosphate (UTP; Uridine 5'-triphosphate) is a pyrimidine nucleoside triphosphate that is used as a substrate to synthesize RNA or as an energy source in metabolic reactions. Uridine triphosphate activates membrane-bound P2Y2 receptors .
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Cat. No.: HY-17026A
CAS No.: 110988-86-8
Synonyms: dFdCTP
Gemcitabine triphosphate (dFdCTP) is the active metabolite of Gemcitabine (HY-17026). The mechanism of Gemcitabine triphosphate cell-killing is its competition with cytidine triphosphate during DNA replication, which results in the inhibition of chain elongation. Gemcitabine triphosphate shows a Ki of 11.2 μM against DNA polymerase α and 14.4 μM against DNA polymerase ε. Gemcitabine triphosphate partially inhibits dCMP deaminase and acts as a substrate for DNA synthesis to incorporate into cellular DNA and RNA. Gemcitabine triphosphate disrupts DNA and RNA synthesis, arrests cell cycle in G0/G1 and S phases, triggers apoptosis, reduces tumor cell proliferation. Gemcitabine triphosphate can be used for the research of pancreatic cancer and non-small cell lung cancer .
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Cat. No.: HY-131596B
CAS No.: 1188407-46-6
Purity:  99.06%
Synonyms: (-)-Emtricitabine triphosphate tetrasodium salt
Emtricitabine triphosphate tetrasodium salt ((-)-Emtricitabine triphosphate tetrasodium salt) is the phosphorylated active metabolite of Emtricitabine (HY-17427). Emtricitabine triphosphate inhibits HIV-1 reverse transcriptase and incorporates into the nascent viral DNA chain, causing chain termination. Emtricitabine triphosphate tetrasodium salt can serve as a biomarker for assessing adherence to antiretroviral therapy. Emtricitabine triphosphate (tetrasodium salt) can be used in research related to HIV infection .
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