Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
262 Results for "
breaks
" in MedChemExpress (MCE) Product Catalog:
Products (262)
262 Results for "breaks" in MCE Product Catalog:
Cat. No.: HY-162959
CAS No.: 2254567-00-3
Target:
Research Areas:
BWC0977 acts as an inhibitor of bacterial Topoisomerase. BWC0977 stabilizes single-strand DNA breaks, inhibits DNA supercoiling and decatenation activities, binds to GyrA and ParC residues, and activates the SOS response. BWC0977 can be used in research related to multidrug-resistant bacterial infections .
Target:
Research Areas:
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .
Cat. No.: HY-13550
CAS No.: 64862-96-0
Synonyms: NSC 196473; NSC 290813
Target:
Research Areas:
Ametantrone (NSC 196473) is an antitumor agent that intercalates into DNA and induces topoisomerase II (TOP2)-mediated DNA break .
Cat. No.: HY-164279
CAS No.: 1207615-74-4
Target:
Research Areas:
YTR107 is a radiation sensitizer. YTR107 binds to nucleophosmin1 (NPM1) and inhibits pentamer formation. YTR107 inhibits recruitment of nucleophosmin to sites of DNA damage, suppresses repair of DNA double strand breaks, and enhances radiosensitization .
Target:
Research Areas:
Bilirubin Conjugate disodium is a peroxyl radical scavenger and chain-breaking antioxidant that inhibits lipid peroxidation by undergoing addition reactions with pyrrole moieties and accelerates copper ion-catalyzed decomposition of lipid hydroperoxides. Bilirubin Conjugate disodium is used in oxidative stress-related research .
Cat. No.: HY-W543137
CAS No.: 727721-37-1
Cat. No.: HY-D1023
CAS No.: 102212-99-7
Synonyms: 5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt
Target:
Research Areas:
Fumarase catalyses the conversion of l-malic acid to fumaric acid. Fumarase participates in the tricarboxylic acid cycle in mitochondria. Fumarase participates in the cellular response to DNA double strand breaks .
Target:
Research Areas:
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity . 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells .
Cat. No.: HY-N7147
CAS No.: 56495-82-0
Target:
Cat. No.: HY-149348
CAS No.: 3052259-89-6
Target:
Research Areas:
DiPT-4 is a dual TOP1/PARP1 inhibitor that induces massive DNA double-strand breaks (DSBs), cell cycle arrest, and apoptosis in cancer cells. DiPT-4 has the potential to overcome cancer drug resistance .
Cat. No.: HY-W076740
CAS No.: 6974-78-3
Synonyms: 8-Bromo-9H-purin-6-amine
Cat. No.: HY-123232
CAS No.: 623578-11-0
KU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair .
Cat. No.: HY-N4120
CAS No.: 51771-49-4
Category:
Iridoids Terpenoids Valeriana hardwickei Wall. Plants Caprifoliaceae Extract Lonicera macrantha (D. Don) Spreng.
Target:
Cat. No.: HY-W749297
CAS No.: 9060-10-0
Synonyms: Phleomycin D2
Category:
Target:
Cat. No.: HY-18626
CAS No.: 208237-49-4
Target:
Research Areas:
NK 314 is an inhibitor for topoisomerase IIα, which generates the break of DNA double-strand. NK 314 arrests the cell cycle at G2 phase in human acute myeloid leukemia cells, inhibits the proliferation of CEM with IC90 of 55 nM .
Cat. No.: HY-13703
CAS No.: 42471-28-3
Research Areas:
Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity .
Cat. No.: HY-174499
Cas9 Nickase D10A mRNA expresses a version of the Streptococcus pyogenes SF370 Cas9 protein (CRISPR Associated Protein 9) that contains a D10A amino acid substitution. This mRNA also contains a C-terminal nuclear localization signal followed by a HA tag.Cas9 functions as part of the CRISPR (clustered regularly interspaced short palindromic repeats) genome editing system. In the CRISPR system, an RNA guide sequence targets the site of interest and the Cas9 protein is employed to perform the DNA cleavage. While wild-type Cas9 creates a double-stranded break at the target site, Cas9 nickase creates a single-stranded break. This favors homology-directed repair and decreases the occurrence of non-homologous end joining.
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
